Results 1 to 10 of about 16,675 (216)

Disulfiram Transcends ALDH Inhibitory Activity When Targeting Ovarian Cancer Tumor-Initiating Cells

Frontiers in Oncology, 2022
Epithelial ovarian cancer (EOC) is a global health burden and remains the fifth leading cause of cancer related death in women worldwide with the poorest five-year survival rate of the gynecological malignancies. EOC recurrence is considered to be driven
Michael W. Caminear, Brittney S. Harrington, Rahul D. Kamdar, Michael J. Kruhlak, Christina M. Annunziata   +4 more
doaj   +2 more sources

Anti-alcoholism drug disulfiram inhibits PANoptosis by blocking mitochondrial permeabilization in macrophages [PDF]

Frontiers in Immunology
IntroductionPANoptosis is a form of inflammatory cell death that exhibits simultaneous activation of pyroptosis, apoptosis and necroptosis signaling. Disulfiram is a clinically used anti-alcoholism drug and can inhibit NLRP3 inflammasome activation and ...
Ya-ping Li, Ya-ping Li, Xin-jian Niu, Ge Zhang, On-kei Chan, Nuo Sun, Bo Hu, Zi-jian Shi, Dong-yun Ouyang, Dong-yun Ouyang, Xian-hui He, Xian-hui He, Qing-bing Zha, Qing-bing Zha   +13 more
doaj   +2 more sources

Disulfiram inhibits bacterial growth by inducing zinc-dependent reactive oxygen species [PDF]

Frontiers in Microbiology
IntroductionThe discovery of novel antimicrobial mechanisms among existing clinical drugs is urgently needed. Disulfiram, an FDA-approved treatment for alcohol dependence, exhibits broad-spectrum antibacterial effects.
Qinyu Luo, Zehua Wu, Yihang Pan, Yan Zhang   +3 more
doaj   +2 more sources

Disulfiram implantation in alcohol dependency: influence of sociodemographic and clinical variables on treatment response

Psychiatry and Clinical Psychopharmacology, 2021
Objective: Psychopharmacological, psychotherapeutic and psychosocial treatment methods are being used in alcohol dependence, which is a frequently occurring psychiatric disorder.
Asli Akin Aslan, Ozhan Yalcin, Zehra Arikan, Asli Kuruoglu, Behcet Cosar, Numan Konuk   +5 more
doaj   +1 more source

Disulfiram Protects Against Radiation-Induced Intestinal Injury in Mice

Frontiers in Pharmacology, 2022
Radiation-induced intestinal injury (RIII) occurs after high doses of radiation exposure. RIII restricts the therapeutic efficacy of radiotherapy in cancer and increases morbidity and mortality in nuclear disasters.
Qingwen Yuan, Renjun Peng, Huijie Yu, Sinian Wang, Zhongmin Chen, Suhe Dong, Wei Li, Bo Cheng, Qisheng Jiang, Yuwen Cong, Fengsheng Li, Changzheng Li   +11 more
doaj   +1 more source

Disulfiram Produces Potent Anxiolytic-Like Effects Without Benzodiazepine Anxiolytics-Related Adverse Effects in Mice

Frontiers in Pharmacology, 2022
Disulfiram is an FDA approved drug for the treatment of alcoholism. The drug acts by inhibiting aldehyde dehydrogenase, an enzyme essential to alcohol metabolism.
Akiyoshi Saitoh, Yoshifumi Nagayama, Daisuke Yamada, Kosho Makino, Toshinori Yoshioka, Nanami Yamanaka, Momoka Nakatani, Yoshino Takahashi, Mayuna Yamazaki, Chihiro Shigemoto, Misaki Ohashi, Kotaro Okano, Tomoki Omata, Etsuko Toda, Etsuko Toda, Yoshitake Sano, Hideyo Takahashi, Kouji Matsushima, Yuya Terashima   +18 more
doaj   +1 more source

Targeting NPL4 via drug repositioning using disulfiram for the treatment of clear cell renal cell carcinoma.

PLoS ONE, 2020
The alcohol-abuse drug disulfiram has antitumor effects against diverse cancer types via inhibition of the ubiquitin-proteasome protein nuclear protein localization protein 4 (NPL4).
Hirofumi Yoshino, Yasutoshi Yamada, Hideki Enokida, Yoichi Osako, Masafumi Tsuruda, Kazuki Kuroshima, Takashi Sakaguchi, Satoshi Sugita, Shuichi Tatarano, Masayuki Nakagawa   +9 more
doaj   +1 more source

Disulfiram efficacy in the treatment of alcohol dependence: a meta-analysis. [PDF]

PLoS ONE, 2014
BACKGROUND: Despite its success with compliant or supervised patients, disulfiram has been a controversial medication in the treatment of alcoholism. Often, study designs did not recognize a pivotal factor in disulfiram research, the importance of an ...
Marilyn D Skinner, Pierre Lahmek, Héloïse Pham, Henri-Jean Aubin   +3 more
doaj   +1 more source

The impact of disulfiram treatment on the reinforcing effects of cocaine: a randomized clinical trial. [PDF]

PLoS ONE, 2012
Clinical trials indicate that disulfiram (250 mg/d) reduces cocaine use, though one study found that treatment with lower doses of disulfiram (62.5 and 125 mg/d) increased cocaine use.
Colin N Haile, Richard De La Garza, James J Mahoney, David A Nielsen, Thomas R Kosten, Thomas F Newton   +5 more
doaj   +1 more source

Recognition of a disulfiram ethanol reaction in the emergency department is not always straightforward.

PLoS ONE, 2020
ObjectivesDisulfiram is an adjunct in the treatment of alcohol use disorders, but case reports indicate that disulfiram ethanol reactions are not always recognized in the emergency department. Our first aim is to remind of this risk with two case reports
Kristof Segher, Liesbeth Huys, Tania Desmet, Evi Steen, Stefanie Chys, Walter Buylaert, Peter De Paepe   +6 more
doaj   +1 more source