Results 31 to 40 of about 16,675 (216)

Disulfiram Hepatitis

Gastroenterology, 1978
A case of an adult with disulfiram-induced hepatitis is presented. An etiological role for the drug was proved when the patient underwent a provocative challenge and developed evidence of hepatocellular damage, reversible on withdrawal of the drug. Disulfiram-induced liver injury is difficult to detect in a population with a high incidence of alcohol ...
S J, Morris, R, Kanner, R O, Chiprut, E R, Schiff   +3 more
openaire   +2 more sources

Evaluation of Disulfiram Drug Combinations and Identification of Other More Effective Combinations against Stationary Phase Borrelia burgdorferi

Antibiotics, 2020
Lyme disease, caused by Borrelia burgdorferi, is the most common vector-borne disease in USA, and 10–20% of patients will develop persistent symptoms despite treatment (“post-treatment Lyme disease syndrome”). B.
Hector S. Alvarez-Manzo, Yumin Zhang, Wanliang Shi, Ying Zhang   +3 more
doaj   +1 more source

Disulfiram-induced psychosis at a therapeutic dose and in clear sensorium: Two case demonstrations

Journal of Mental Health and Human Behaviour, 2019
The literature on disulfiram induced psychosis showed, it was either associated with delirium or preceded by a prescription of a higher dose. We report two cases of psychosis in clear sensorium developing in individuals with alcohol dependence without ...
Abhishek Ghosh, Debasish Basu, C Pradeep, B N Subodh   +3 more
doaj   +1 more source

Chronic inhibition of dopamine β-hydroxylase facilitates behavioral responses to cocaine in mice. [PDF]

PLoS ONE, 2012
The anti-alcoholism medication, disulfiram (Antabuse), decreases cocaine use in humans regardless of concurrent alcohol consumption and facilitates cocaine sensitization in rats, but the functional targets are unknown.
Meriem Gaval-Cruz, Larry Cameron Liles, Paul Michael Iuvone, David Weinshenker   +3 more
doaj   +1 more source

Disulfiram, an aldehyde dehydrogenase inhibitor, works as a potent drug against sepsis and cancer via NETosis, pyroptosis, apoptosis, ferroptosis, and cuproptosis

Blood Science, 2022
Regulated cell death (RCD) is essential for maintaining cell homeostasis and preventing diseases. Besides classical apoptosis, several novel nonapoptotic forms of RCD including NETosis, pyroptosis, ferroptosis, and cuproptosis have been reported and are ...
Dingrui Nie, Cun-te Chen, Yangqiu Li, Chengwu Zeng   +3 more
semanticscholar   +1 more source

A Case of Psychosis in Disulfiram Treatment for Alcoholism

Case Reports in Psychiatry, 2014
Background. Disulfiram, a drug used in the treatment of alcohol dependence, is an inhibitor of dopamine-β-hydroxylase causing an increase in the concentration of dopamine in the mesolimbic system.
Raquel Calvão de Melo, Rui Lopes, José Carlos Alves   +2 more
doaj   +1 more source

Disulfiram use is associated with lower risk of COVID-19: A retrospective cohort study

PLoS ONE, 2021
Effective, low-cost therapeutics are needed to prevent and treat COVID-19. Severe COVID-19 disease is linked to excessive inflammation. Disulfiram is an approved oral drug used to treat alcohol use disorder that is a potent anti-inflammatory agent and an
Nathanael Fillmore, Steven Bell, Ciyue Shen, Vinh Nguyen, Jennifer La, Maureen Dubreuil, Judith Strymish, Mary Brophy, Gautam Mehta, Hao Wu, Judy Lieberman, Nhan Do, Chris Sander   +12 more
doaj   +2 more sources

Combined treatment of disulfiram with PARP inhibitors suppresses ovarian cancer

Frontiers in Oncology, 2023
IntroductionDue to the difficulty of early diagnosis, nearly 70% of ovarian cancer patients are first diagnosed at an advanced stage. Thus, improving current treatment strategies is of great significance for ovarian cancer patients. Fast-developing poly (
Bin Tang, Min Wu, Lin Zhang, Shuyi Jian, Shiyi Lv, Tongyuan Lin, Shuangshuang Zhu, Layang Liu, Yixue Wang, Zhengfang Yi, Feiyun Jiang   +10 more
doaj   +1 more source

Alcohol-abuse drug disulfiram targets cancer via p97 segregase adapter NPL4

Nature, 2017
Cancer incidence is rising and this global challenge is further exacerbated by tumour resistance to available medicines. A promising approach to meet the need for improved cancer treatment is drug repurposing.
Zdenek Skrott, M. Mistrik, K. K. Andersen, S. Friis, Dusana Majera, J. Gursky, T. Oždian, J. Bártková, Zsófia Turi, Pavel Moudrý, M. Kraus, M. Michalová, Jana Václavková, P. Džubák, Ivo Vrobel, P. Poučková, J. Sedlácek, Andrea Miklovicova, Anne Kutt, Jing Li, J. Mattová, C. Driessen, Q. Dou, Jørgen H. Olsen, M. Hajdůch, B. Cvek, R. Deshaies, J. Bartek   +27 more
semanticscholar   +1 more source

Disulfiram/Copper Induces Antitumor Activity against Both Nasopharyngeal Cancer Cells and Cancer-Associated Fibroblasts through ROS/MAPK and Ferroptosis Pathways

Cancers, 2020
Disulfiram/copper (DSF/Cu) is a promising antitumor reagent for clinical application due to its excellent anticancer activity and safety. However, the anticancer mechanism of DSF/Cu has not been fully elucidated.
Yiqiu Li, Fangfang Chen, Jun Chen, S. Chan, Yi He, Wanli Liu, Ge Zhang   +6 more
semanticscholar   +1 more source