Results 41 to 50 of about 16,675 (216)
Disulfiram-loaded lactoferrin nanoparticles for treating inflammatory diseases
Acta Pharmacologica Sinica, 2021 Sepsis is a dysregulated immune response to infection and potentially leads to life-threatening organ dysfunction, which is often seen in serious Covid-19 patients.
A. Ou +8 more
semanticscholar +1 more source
Disulfiram-alcohol reaction in 49 year old patient
Journal of Education, Health and Sport, 2018 Alcoholism is a disease in which person lose control over the amount of consumed alcohol. The problem of alcohol abuse in Poland concerns about 9% of the population. One of the treatment methods is disulfiram therapy, which is associated with the risk of
Krystian Lech Ciechański +5 more
doaj +3 more sources
Disulfiram: A novel repurposed drug for cancer therapy
Chinese Medical JournalCancer is a major global health issue. Effective therapeutic strategies can prolong patients' survival and reduce the costs of treatment. Drug repurposing, which identifies new therapeutic uses for approved drugs, is a promising approach with the ...
Min Zeng +6 more
semanticscholar +1 more source
Frontiers in Psychiatry, 2013 Objective: Disulfiram is a one of the few pharmacotherapies for cocaine addiction that shows promise. Since disulfiram and cocaine both affect levels of global methylation we hypothesized the MTHFR gene, whose product is involved in supplying methyl ...
Catherine eSpellicy +4 more
doaj +1 more source
International journal of pharmaceuticsDrug repositioning is a high-priority and feasible strategy in the field of oncology research, where the unmet medical needs are continuously unbalanced. Disulfiram is a potential non-chemotherapeutic, adjuvant anticancer agent.
Beáta-Mária Benkő +11 more
semanticscholar +1 more source
Kidney International, 2022 Activated monocytes/macrophages promote glomerular injury, including crescent formation, in anti-glomerular basement membrane (GBM) glomerulonephritis. Disulfiram, an alcohol-aversion drug, inhibits monocyte/macrophage migration by inhibiting FROUNT, a ...
E. Toda +17 more
semanticscholar +1 more source
Topical inflammasome inhibition with disulfiram prevents irritant contact dermatitis
Clinical and Translational Allergy, 2021 Background The pathogenesis of contact dermatitis, a common inflammatory skin disease with limited treatment options, is held to be driven by inflammasome activation induced by allergens and irritants.
Hanna Bonnekoh +13 more
doaj +1 more source
Novel Disulfiram Derivatives as ALDH1a1-Selective Inhibitors
Molecules, 2022 Aldehyde dehydrogenase-1a1 (ALDH1a1), the enzyme responsible for the oxidation of retinal into retinoic acid, represents a key therapeutic target for the treatment of debilitating disorders such as cancer, obesity, and inflammation.
Ziad Omran
doaj +1 more source
Advanced Science, EarlyView.Under colitis, Gsdmd mediates the release of IL‐33 from the epithelium of pregnant mice. IL‐33 can cross the placenta and enhance the proliferative capacity of neural stem cells, ultimately resulting in behavioral deficits in the offspring. Excessive pyroptosis in the colonic epithelium also triggers the translocation of LPS, which in turn increases ...
Huiyang Jia +4 more
wiley +1 more source
FDA-approved disulfiram as a novel treatment for aggressive leukemia
Journal of molecular medicineAcute leukemia continues to be a major cause of death from disease worldwide and current chemotherapeutic agents are associated with significant morbidity in survivors.
M. Karsa +19 more
semanticscholar +1 more source