Results 21 to 30 of about 16,675 (216)

Effect of Disulfiram and Copper Plus Chemotherapy vs Chemotherapy Alone on Survival in Patients With Recurrent Glioblastoma

JAMA Network Open, 2023
Key Points Question Does the addition of disulfiram and copper to chemotherapy improve survival for patients with recurrent glioblastoma? Findings In this randomized clinical trial of 88 patients with recurrent glioblastoma, the addition of disulfiram ...
K. Werlenius, S. Kinhult, T. Solheim, H. Magelssen, D. Löfgren, M. Mudaisi, S. Hylin, Jiri Bartek, M. Strandéus, M. Lindskog, Havyan Bahroz Rashid, L. Carstam, S. Gulati, O. Solheim, Jiri Bartek, Ø. Salvesen, A. Jakola   +16 more
semanticscholar   +1 more source

Disulfiram inhibits neutrophil extracellular trap formation and protects rodents from acute lung injury and SARS-CoV-2 infection

JCI Insight, 2022
Severe acute lung injury has few treatment options and a high mortality rate. Upon injury, neutrophils infiltrate the lungs and form neutrophil extracellular traps (NETs), damaging the lungs and driving an exacerbated immune response.
J. M. Adrover, L. Carrau, J. Daßler-Plenker, Y. Bram, Vasuretha Chandar, S. Houghton, D. Redmond, Joseph R. Merrill, Margaret Shevik, B. tenOever, S. Lyons, R. Schwartz, M. Egeblad   +12 more
semanticscholar   +1 more source

Health disparities in chronic liver disease

Hepatology, EarlyView., 2022
Abstract The syndemic of hazardous alcohol consumption, opioid use, and obesity has led to important changes in liver disease epidemiology that have exacerbated health disparities. Health disparities occur when plausibly avoidable health differences are experienced by socially disadvantaged populations.
Ani Kardashian, Marina Serper, Norah Terrault, Lauren D. Nephew   +3 more
wiley   +1 more source

Disulfiram ameliorates nonalcoholic steatohepatitis by modulating the gut microbiota and bile acid metabolism

Nature Communications, 2022
Nonalcoholic steatohepatitis (NASH) has been linked with the gut-liver axis. Here, we investigate the potential for repurposing disulfiram (DSF), a drug commonly used to treat chronic alcoholism, for NASH.
Yuanyuan Lei, Li Tang, Qiao Chen, Lingyi Wu, Wei He, Dianji Tu, Sumin Wang, Yuyang Chen, Shuang Liu, Zhuo Xie, Hong Wei, Shiming Yang, Bo Tang   +12 more
semanticscholar   +1 more source

Disulfiram/Copper Induces Immunogenic Cell Death and Enhances CD47 Blockade in Hepatocellular Carcinoma

Cancers, 2022
Simple Summary The combination of disulfiram and copper is a novel anti-cancer drug under clinical development for the treatment of several tumor types including hepatocellular carcinoma.
Xingxing Gao, Hechen Huang, C. Pan, Zhibin Mei, Shengyong Yin, Lin Zhou, Shusen Zheng   +6 more
semanticscholar   +1 more source

Drug Repurposing as an Antitumor Agent: Disulfiram-Mediated Carbonic Anhydrase 12 and Anion Exchanger 2 Modulation to Inhibit Cancer Cell Migration

Molecules, 2019
Disulfiram has been used in the treatment of alcoholism and exhibits an anti-tumor effect. However, the intracellular mechanism of anti-tumor activity of Disulfiram remains unclear.
Soyoung Hwang, Dong Min Shin, Jeong Hee Hong   +2 more
doaj   +1 more source

Recent Advances in Repurposing Disulfiram and Disulfiram Derivatives as Copper-Dependent Anticancer Agents

Frontiers in Molecular Biosciences, 2021
Copper (Cu) plays a pivotal role in cancer progression by acting as a co-factor that regulates the activity of many enzymes and structural proteins in cancer cells. Therefore, Cu-based complexes have been investigated as novel anticancer metallodrugs and
V. Kannappan, Misha Ali, B. Small, G. Rajendran, Salena Elzhenni, Hamza Taj, Weiguang Wang, Q. Dou   +7 more
semanticscholar   +1 more source

Chemical biology drug sensitivity screen identifies sunitinib as synergistic agent with disulfiram in prostate cancer cells. [PDF]

PLoS ONE, 2012
Current treatment options for castration- and treatment-resistant prostate cancer are limited and novel approaches are desperately needed. Our recent results from a systematic chemical biology sensitivity screen covering most known drugs and drug-like ...
Kirsi Ketola, Olli Kallioniemi, Kristiina Iljin   +2 more
doaj   +1 more source

Europe's contribution to the evaluation of the use of systemic antimicrobials in the treatment of periodontitis

Periodontology 2000, EarlyView., 2023
Abstract This narrative review celebrates Europe's contribution to the current knowledge on systemically administered antimicrobials in periodontal treatment. Periodontitis is the most frequent chronic noncommunicable human disease. It is caused by dysbiotic bacterial biofilms and is commonly treated with subgingival instrumentation.
David Herrera, Arie Jan van Winkelhoff, Paula Matesanz, Katalina Lauwens, Wim Teughels   +4 more
wiley   +1 more source

Ebselen, Disulfiram, Carmofur, PX-12, Tideglusib, and Shikonin Are Nonspecific Promiscuous SARS-CoV-2 Main Protease Inhibitors

ACS Pharmacology & Translational Science, 2020
Among the drug targets being investigated for SARS-CoV-2, the viral main protease (Mpro) is one of the most extensively studied. Mpro is a cysteine protease that hydrolyzes the viral polyprotein at more than 11 sites.
Chunlong Ma, Yanmei Hu, J. A. Townsend, Panagiotis Lagarias, M. Marty, A. Kolocouris, Jun Wang   +6 more
semanticscholar   +1 more source