Results 41 to 50 of about 21,323 (190)

Benzophenone Derivatives as a New Class of Anti‐Infectives Against Acanthamoeba spp

Archiv der Pharmazie, Volume 359, Issue 8, August 2026.
Analogues of the human oxidosqualene cyclase inhibitor Ro 48‐8071 were designed, synthesized, and tested against Acanthamoeba hatchetti, one of the pathogens causing Acanthamoeba keratitis. The N‐propargyl derivative 4f showed strong amoebicidal activity with complete eradication of trophozoites and cysts, while exhibiting low toxicity toward human ...
Tomas Rimkus, Hannes Geisler, Taha B. El‐Jourani, Aurélien F. A. Moumbock, Matthias Schiedel, Stephan Reichl   +5 more
wiley   +1 more source

Microenvironment‐Responsive Drug Delivery Systems for Ocular Surface Diseases: Mechanisms, Applications, and Translational Challenges

Small Science, Volume 6, Issue 8, August 2026.
Microenvironment‐responsive drug delivery systems overcome ocular physiological barriers by responding to temperature, pH, ions, reactive oxygen species, and enzymes. This review bridges material design, performance evaluation, and clinical translation, offering actionable insights for treating dry eye disease, infectious keratitis, and corneal ...
Jiamin Liu, Liangbo Chen, Yao Fu, Siyi Zhang   +3 more
wiley   +1 more source

An update on Acanthamoeba keratitis: diagnosis, pathogenesis and treatment

Parasite, 2015
Free-living amoebae of the genus Acanthamoeba are causal agents of a severe sight-threatening infection of the cornea known as Acanthamoeba keratitis. Moreover, the number of reported cases worldwide is increasing year after year, mostly in contact lens ...
Lorenzo-Morales Jacob, Khan Naveed A., Walochnik Julia   +2 more
doaj   +1 more source

Commensals Serve as Natural Barriers to Mammalian Cells during Acanthamoeba castellanii Invasion

Microbiology Spectrum, 2021
Acanthamoeba castellanii is a free-living, pathogenic ameba found in the soil and water. It invades the body through ulcerated skin, the nasal passages, and eyes and can cause blinding keratitis and granulomatous encephalitis.
Yu-Jen Wang, Chun-Hsien Chen, Jenn-Wei Chen, Wei-Chen Lin   +3 more
doaj   +1 more source

Therapeutic Gases in Biomedicine: Updates on Nitric Oxide and Beyond

Advanced Science, Volume 13, Issue 23, 23 April 2026.
Therapeutic gases, including NO, CO, H2S, H2, CO2, O2, and Xe, play vital roles in cellular signaling and repair. This review highlights the emerging carriers and delivery systems that enable controlled, localized gas release for diagnostic and therapeutic applications.
Syed Muntazir Andrabi, Navatha Shree Sharma, Imran Ibn Gani Rather, S. M. Shatil Shahriar, Jingwei Xie   +4 more
wiley   +1 more source

Etiology and Risk Factors for Infectious Keratitis in South Texas

Journal of Ophthalmic & Vision Research, 2020
Purpose: To determine the causative organisms and associated risk factors for infectious keratitis in South Texas. Methods: This retrospective study was performed at a tertiary teaching hospital system in South Texas. Medical records of all patients
Madeleine Puig, Menachem Weiss, Ricardo Salinas, Daniel A Johnson, Ahmad Kheirkhah   +4 more
doaj   +1 more source

Evaluating quality of patient‐reported outcome measures in keratitis: A systematic review

Optometry and Vision Science, Volume 103, Issue 4, April 2026.
ABSTRACT Purpose To evaluate the quality of existing patient‐reported outcome measures (PROMs) used to assess the impact of keratitis on the quality of life (QoL). Methods A literature search was conducted using Embase, PubMed, Scopus, Web of Science, CINAHL, and PsycINFO. The review included PROMs used to assess the impact of keratitis on QoL. Data on
Haile W. Alemu, Sheela E. Kumaran, Nicole Carnt, Aragaw K. Assaye, Pawan Baral, Konrad Pesudovs   +5 more
wiley   +1 more source

Genotyping and phylogenic study of Acanthamoeba isolates from human keratitis and swimming pool water samples in Iran

Parasite Epidemiology and Control, 2020
Objective: Acanthamoeba keratitis cause severe corneal infection and lead to poor vision and blindness. This disease is caused by a unicellular amphizoic protozoon called Acanthamoeba spp. that present in different environments.
Bahman Rahimi Esboei, Mahdi Fakhar, Reza Saberi, Mohammad Barati, Masoumeh Moslemi, Hadi Hassannia, Yousef Dadimoghadam, Nahid Jalallou   +7 more
doaj   +1 more source

The pathogenesis of Acanthamoeba keratitis [PDF]

Australian and New Zealand Journal of Ophthalmology, 1991
AbstractMost major eye centres in Australia have now seen patients with corneal infection due to Acanthamoeba. The medical treatment of this condition is difficult; Acanthamoeba isolates show wide variation in their susceptibility to antimicrobial agents and amoebicidal concentrations are difficult to achieve in the cornea.
openaire   +2 more sources

What We Can Do in Infectious Keratitis, Except for Conventional Antimicrobial‐Based Therapies: Major Narrative Review

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background and Aims Infectious keratitis (IK) is classified as a critical ophthalmic emergency, with the potential to result in vision‐impairing complications. The treatment approach involves the use of pharmacological antimicrobial agents in combination with surgical interventions.
Kasra Cheraqpour
wiley   +1 more source