Results 31 to 40 of about 3,757 (169)

Microenvironment‐Responsive Drug Delivery Systems for Ocular Surface Diseases: Mechanisms, Applications, and Translational Challenges

Small Science, Volume 6, Issue 8, August 2026.
Microenvironment‐responsive drug delivery systems overcome ocular physiological barriers by responding to temperature, pH, ions, reactive oxygen species, and enzymes. This review bridges material design, performance evaluation, and clinical translation, offering actionable insights for treating dry eye disease, infectious keratitis, and corneal ...
Jiamin Liu, Liangbo Chen, Yao Fu, Siyi Zhang   +3 more
wiley   +1 more source

An update on Acanthamoeba keratitis: diagnosis, pathogenesis and treatment

Parasite, 2015
Free-living amoebae of the genus Acanthamoeba are causal agents of a severe sight-threatening infection of the cornea known as Acanthamoeba keratitis. Moreover, the number of reported cases worldwide is increasing year after year, mostly in contact lens ...
Lorenzo-Morales Jacob, Khan Naveed A., Walochnik Julia   +2 more
doaj   +1 more source

Commensals Serve as Natural Barriers to Mammalian Cells during Acanthamoeba castellanii Invasion

Microbiology Spectrum, 2021
Acanthamoeba castellanii is a free-living, pathogenic ameba found in the soil and water. It invades the body through ulcerated skin, the nasal passages, and eyes and can cause blinding keratitis and granulomatous encephalitis.
Yu-Jen Wang, Chun-Hsien Chen, Jenn-Wei Chen, Wei-Chen Lin   +3 more
doaj   +1 more source

Therapeutic Gases in Biomedicine: Updates on Nitric Oxide and Beyond

Advanced Science, Volume 13, Issue 23, 23 April 2026.
Therapeutic gases, including NO, CO, H2S, H2, CO2, O2, and Xe, play vital roles in cellular signaling and repair. This review highlights the emerging carriers and delivery systems that enable controlled, localized gas release for diagnostic and therapeutic applications.
Syed Muntazir Andrabi, Navatha Shree Sharma, Imran Ibn Gani Rather, S. M. Shatil Shahriar, Jingwei Xie   +4 more
wiley   +1 more source

Acanthamoeba Keratitis: Perspectives for Patients

Current Eye Research, 2020
Purpose: To unveil the long-term prognosis of Acanthamoeba keratitis based on clinical presentation and timing of diagnosis to better inform patients since the first visit regarding their length of treatment, quality of life, and visual function.Methods: Retrospective observational study enrolling patients with Acanthamoeba keratitis from 1994 to 2019.
Bonini, Stefano, Di Zazzo, Antonio, Varacalli, Giuseppe, Coassin, Marco   +3 more
openaire   +2 more sources

Etiology and Risk Factors for Infectious Keratitis in South Texas

Journal of Ophthalmic & Vision Research, 2020
Purpose: To determine the causative organisms and associated risk factors for infectious keratitis in South Texas. Methods: This retrospective study was performed at a tertiary teaching hospital system in South Texas. Medical records of all patients
Madeleine Puig, Menachem Weiss, Ricardo Salinas, Daniel A Johnson, Ahmad Kheirkhah   +4 more
doaj   +1 more source

Evaluating quality of patient‐reported outcome measures in keratitis: A systematic review

Optometry and Vision Science, Volume 103, Issue 4, April 2026.
ABSTRACT Purpose To evaluate the quality of existing patient‐reported outcome measures (PROMs) used to assess the impact of keratitis on the quality of life (QoL). Methods A literature search was conducted using Embase, PubMed, Scopus, Web of Science, CINAHL, and PsycINFO. The review included PROMs used to assess the impact of keratitis on QoL. Data on
Haile W. Alemu, Sheela E. Kumaran, Nicole Carnt, Aragaw K. Assaye, Pawan Baral, Konrad Pesudovs   +5 more
wiley   +1 more source

Genotyping and phylogenic study of Acanthamoeba isolates from human keratitis and swimming pool water samples in Iran

Parasite Epidemiology and Control, 2020
Objective: Acanthamoeba keratitis cause severe corneal infection and lead to poor vision and blindness. This disease is caused by a unicellular amphizoic protozoon called Acanthamoeba spp. that present in different environments.
Bahman Rahimi Esboei, Mahdi Fakhar, Reza Saberi, Mohammad Barati, Masoumeh Moslemi, Hadi Hassannia, Yousef Dadimoghadam, Nahid Jalallou   +7 more
doaj   +1 more source

What We Can Do in Infectious Keratitis, Except for Conventional Antimicrobial‐Based Therapies: Major Narrative Review

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background and Aims Infectious keratitis (IK) is classified as a critical ophthalmic emergency, with the potential to result in vision‐impairing complications. The treatment approach involves the use of pharmacological antimicrobial agents in combination with surgical interventions.
Kasra Cheraqpour
wiley   +1 more source

Supercationic Poly(Hexamethylene Biguanide)‐Derived Carbon Dots for Combating Multidrug‐Resistant Bacterial Keratitis

Small Structures, Volume 7, Issue 3, March 2026.
This research introduces poly(hexamethylene biguanide)‐derived carbon dots (P‐CDs) as a novel antibacterial agent for combating multidrug‐resistant bacterial keratitis. P‐CDs exhibit potent activity against resistant pathogens, including MRSA and MRPA. In vivo results confirm their superior therapeutic efficacy over standard antibiotics, alongside the ...
Wenjie Fan, Tianji Feng, Hongxian Pan, Yin Zhang, Zhebin Chen, Qiao Jin, Haijie Han, Jian Ji, Ke Yao   +8 more
wiley   +1 more source