Results 71 to 80 of about 2,140,151 (276)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Underlying factors determining grain morphologies in high-strength titanium alloys processed by additive manufacturing

Nature Communications, 2023
In recent research, additions of solute to Ti and some Ti-based alloys have been employed to produce equiaxed microstructures when processing these materials using additive manufacturing.
Mohan S. K. K. Y. Nartu, Brian A. Welk, Srinivas A. Mantri, Nevin L. Taylor, Gopal B. Viswanathan, Narendra B. Dahotre, Rajarshi Banerjee, Hamish L. Fraser   +7 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

An accelerated closed universe

, 2004
We study a model in which a closed universe with dust and quintessence matter components may look like an accelerated flat Friedmann-Robertson-Walker (FRW) universe at low redshifts.
A. Melchiorri, A. Vilenkin, A.A. Starobinsky, A.A. Starobinsky, A.E. Lange, C.L. Bennett, C.S. Kochanck, E.W. Kolb, Francisco Peña, G. Lemaître, J.R. Bond, L. Wang, M. Kamionkowski, Mauricio Cataldo, N. Cruz, P. De Bernardis, P.J.E. Peebles, P.M. Garnavich, R.R. Caldwell, S. del Campo, S. del Campo, S. del Campo, S. Perlmutter, S.W. Hawking, Sergio del Campo, V. Sahni, Y. Mellier   +26 more
core   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

A deep learning approach for semantic segmentation of unbalanced data in electron tomography of catalytic materials

Scientific Reports, 2022
In computed TEM tomography, image segmentation represents one of the most basic tasks with implications not only for 3D volume visualization, but more importantly for quantitative 3D analysis.
Arda Genc, Libor Kovarik, Hamish L. Fraser   +2 more
doaj   +1 more source

Inhomogeneity implies Accelerated Expansion

, 2014
The Einstein equations for an inhomogeneous irrotational dust universe are analysed. A set of mild assumptions, all of which are shared by the standard FLRW type scenarios, results in a model that depends only on the distribution of scalar spatial ...
Skarke, Harald
core   +2 more sources

Future Accelerators [PDF]

AIP Conference Proceedings, 2004
I describe the future accelerator facilities that are currently foreseen for electroweak scale physics, neutrino physics, and nuclear structure. I will explore the physics justification for these machines, and suggest how the case for future accelerators can be made.
openaire   +2 more sources

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Accelerated rare event sampling

, 2015
A sampling procedure for the transition matrix Monte Carlo method is introduced that generates the density of states function over a wide parameter range with minimal coding effort.Comment: 7 pages 7 ...
Yevick, David
core   +1 more source