Results 111 to 120 of about 9,228,267 (373)

Accelerated Aging in HIV Patients [PDF]

Rambam Maimonides Medical Journal, 2012
Life expectancy has been increasing in the last few decades in the Western world and is accompanied by higher occurrence of age-related diseases like metabolic, cardiovascular, and renal diseases and also with a decline in immune functions. In HIV-infected people, due to the use of combination antiretroviral therapy (cART), life expectancy has ...
Keren Meir-Shafrir, Shimon Pollack
openaire   +4 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Protective role of female gender in programmed accelerated renal aging in the rat [PDF]

, 2015
The aging kidney exhibits a progressive decline in glomerular filtration rate, accompanied by inflammatory and oxidative damage. We hypothesized that accelerated, age-related progression of renal injury is ovarian hormones-dependant.
Antus, Attia, August, Baiardi, Baylis, Baylis, Baylis, Baylis, Birn, Bongartz, Bongartz, Botev, Colen, Corman, Cornock, Crofton, Dendooven, Elliot, Everitt, Gerondakis, Gerritsen, Gorriz, Hinton, Joles, Joles, Joles, Jung, Koeners, Langley, Langley-Evans, Langley-Evans, Langley-Evans, Lowry, Macova, Mazairac, McGrath, McMullen, McMullen, McMullen, Miyata, Poggio, Potier, Roesch, Rule, Sahajpal, Sahajpal, Sasser, Schreuder, Sherman, Sherman, Swali, Vanhaesebroeck, Vazquez, Wegorzewska, Wiggins, Woods, Wyndham, Yin, Zheng   +58 more
core   +3 more sources

The effect of early discrimination on accelerated aging among African Americans.

Health Psychology, 2019
OBJECTIVE This study examined the role of depressive symptoms in mediating the relationship between early life experiences of racial discrimination and accelerated aging in adulthood for African Americans (i.e., prediction over a 19-year period, from ...
S. Carter, M. Ong, R. Simons, F. Gibbons, M. Lei, S. Beach   +5 more
semanticscholar   +1 more source

Characterizing epithelial‐mesenchymal transition‐linked heterogeneity in breast cancer circulating tumor cells at a single‐cell level

Molecular Oncology, EarlyView.
In over 50% of non‐metastatic breast cancer patients, circulating tumor cells (CTCs) along the whole epithelial‐mesenchymal transition spectrum are detected. Total CTC number and individual phenotypes relate to aggressive disease characteristics, including lymph node involvement and higher tumor proliferation. At the single‐cell level, mesenchymal CTCs
Justyna Topa, Julia Richert, Tomasz Stokowy, Alicja Staśczak, Mariusz Szajewski, Maciej Ciesielski, Petra M. Grešner, Bartłomiej Tomasik, Łukasz Arcimowicz, Agnieszka Stankiewicz, Grażyna Suchodolska, Elżbieta Senkus, Wiesław Kruszewski, Anna J. Żaczek, Aleksandra Markiewicz   +14 more
wiley   +1 more source

Relativity principles in 1+1 dimensions and differential aging reversal

, 2006
We study the behavior of clocks in 1+1 spacetime assuming the relativity principle, the principle of constancy of the speed of light and the clock hypothesis.
A. L. Macdonald, A. R. Lee, A. R. Lee, B. Mashhoon, B. Mashhoon, C. Duval, C. Duval, D. A. Sardelis, E. Minguzzi, E. Minguzzi, G. S. Asanov, G. Yu. Bogoslovsky, G. Yu. Bogoslovsky, G. Yu. Bogoslovsky, H. Leutwyler, H. Round, J. H. Field, J. M. Lévy-Leblond, R. Weinstock, S. Mahajan, T. Budden, V. Berzi, W. Rindler   +22 more
core   +2 more sources

Correlation between Sub-Tg relaxation processes and mechanical behavior for different hydrothermal ageing conditions in epoxy assemblies [PDF]

, 2010
The aim of this study is to understand aging phenomena by monitoring physical parameters after real and simulated aging experiments. This study focuses on aluminum-epoxy assemblies, which are commonly used on spacecraft structures.
Apicella, Bellenger, Bershtein, Boye, Cognard, Colombini, Comrie, Dodiuk, Gupta, Havriliak, Havriliak, Hedvig, Luo, Maggana, Mijovic, Moy, Nogueira, Ochi, Pangrle   +18 more
core   +1 more source

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

Preparation and characterization of renal cell peptides from fetal rats for their antitumor activity

FEBS Open Bio, EarlyView.
This study aimed to prepare renal cells (RCs) from fetal rats which were digested by enzymes. Candidate peptides RCPs were characterized by capillary HPLC and MS and their bioactivity was predicted using peptideranker. The predicted top 10 bioactive peptides were synthesized.
Zhe Zhang, Yuan Cao, Jing Du, Ying Zhang, Junxia Wang, Ying Yuan, Lianqing Sun   +6 more
wiley   +1 more source

Viability of Soybean Seeds (Glycine Max [L.] Merr.) Varieties Argomulyo and Dena-1 Due to the Exposed on Saturated Steam or Stored at Low Temperatures [PDF]

, 2019
The viability of the seed will be lower if stored longer, as well as seeds that are given the higher intensity of accelerated aging treatment. Is the decrease in viability of the Argomulyo and Dena-1 varieties of soybean seeds during the 0-6 month ...
Hilleri, O. (Okvi), Kamal, M. (Muhammad), Pramono, E. (Eko)   +2 more
core