Results 11 to 20 of about 10,649,676 (300)

Obesity and Accelerated Aging

The Journal of nutrition, health and aging, 2023
The population of older adults with obesity is rapidly increasing. Through shared pathophysiologic mechanisms, obesity exacerbates the age-related decline in physical function, which leads to frailty and disability. Obesity and aging are characterized by
D. Villareal
semanticscholar   +2 more sources

Progeria and accelerated cardiovascular aging

Cardiology Plus, 2018
Hutchinson–Gilford Progeria syndrome (HGPS) is characterized by accelerated aging leading to death in the teen years, usually due to severe coronary and/or carotid disease. The clinical presentation includes stunted growth, alopecia, loss of subcutaneous
Brandon K Walther, Yanhui Li, Rajarajan Amirthalingam Thandavarayan, John P Cooke   +3 more
doaj   +2 more sources

Inflammatory exposure drives long-lived impairment of hematopoietic stem cell self-renewal activity and accelerated aging

Cell Stem Cell, 2022
Summary: Hematopoietic stem cells (HSCs) mediate regeneration of the hematopoietic system following injury, such as following infection or inflammation.
Ruzhica Bogeska, A. Mikecin, P. Kaschutnig, Malak Fawaz, Marleen Büchler-Schäff, D. Le, Miguel Ganuza, A. Vollmer, Stella V. Paffenholz, N. Asada, E. Rodríguez-Correa, F. Frauhammer, F. Buettner, M. Ball, J. Knoch, Sina Stäble, D. Walter, Amelie Petri, Martha J. Carreño-Gonzalez, Vinona Wagner, B. Brors, S. Haas, D. Lipka, M. Essers, V. Weru, T. Holland-Letz, Jan-Philipp Mallm, K. Rippe, Stephan M. Krämer, M. Schlesner, Shannon L McKinney Freeman, M. Florian, K. King, P. Frenette, M. Rieger, M. Milsom   +35 more
semanticscholar   +1 more source

Accelerated Aging Mediates the Associations of Unhealthy Lifestyles with Cardiovascular Disease, Cancer, and Mortality

Journal of The American Geriatrics Society, 2023
With two well‐validated aging measures capturing mortality and morbidity risk, this study examined whether and to what extent aging mediates the associations of unhealthy lifestyles with adverse health outcomes.
Xueqin Li, Xingqi Cao, Jingyun Zhang, Jinjing Fu, Mayila Mohedaner, Zhuogadanzeng, Xiaoyi Sun, Gan Yang, Zhenqing Yang, Chia‐Ling Kuo, Xi Chen, Alan A Cohen, Zuyun Liu   +12 more
semanticscholar   +1 more source

Accelerated biological aging and risk of depression and anxiety: evidence from 424,299 UK Biobank participants

Nature Communications, 2023
Theory predicts that biological processes of aging may contribute to poor mental health in late life. To test this hypothesis, we evaluated prospective associations between biological age and incident depression and anxiety in 424,299 UK Biobank ...
Xu Gao, Tong Geng, M. Jiang, N. Huang, Yinan Zheng, Daniel W Belsky, Tao Huang   +6 more
semanticscholar   +1 more source

Use of Correct and Incorrect Methods of Accounting for Age in Studies of Epigenetic Accelerated Aging: Implications and Recommendations for Best Practices

American Journal of Epidemiology, 2023
Motivated by our conduct of a literature review on social exposures and accelerated aging as measured by a growing number of epigenetic “clocks” (which estimate age via DNA methylation (DNAm) patterns), we report on 3 different approaches in the ...
N. Krieger, Jarvis T. Chen, C. Testa, A. D. Diez Roux, K. Tilling, S. Watkins, A. Simpkin, M. Suderman, G. Davey Smith, I. De Vivo, Pamela Waterman, C. Relton   +11 more
semanticscholar   +1 more source

Mendelian randomization supports causality between overweight status and accelerated aging

Aging Cell, 2023
It is reported that overweight may lead to accelerated aging. However, there is still a lack of evidence on the causal effect of overweight and aging.
Zong Chen, Zhiyou Chen, Xiaolei Jin
semanticscholar   +1 more source

Induction of Accelerated Aging in a Mouse Model

Cells, 2022
With the global increase of the elderly population, the improvement of the treatment for various aging-related diseases and the extension of a healthy lifespan have become some of the most important current medical issues.
N. Cai, Yifan Wu, Yan Huang
semanticscholar   +1 more source

Obesity and accelerated epigenetic aging in a high-risk cohort of children

Scientific Reports, 2022
New insights into mechanisms linking obesity to poor health outcomes suggest a role for cellular aging pathways, casting obesity as a disease of accelerated biological aging. Although obesity has been linked to accelerated epigenetic aging in middle-aged
Laura Etzel, Waylon J. Hastings, Molly A. Hall, Christine M. Heim, Michael J. Meaney, Jennie G. Noll, Kieran J. O’Donnell, Irina Pokhvisneva, Emma J. Rose, Hannah M. C. Schreier, Chad E. Shenk, Idan Shalev   +11 more
doaj   +1 more source

Accelerated aging with HIV begins at the time of initial HIV infection

iScience, 2022
Summary Living with HIV infection is associated with early onset of aging-related chronic conditions, sometimes described as accelerated aging. Epigenetic DNA methylation patterns can evaluate acceleration of biological age relative to chronological age.
E. Breen, M. Sehl, R. Shih, P. Langfelder, Ruibin Wang, S. Horvath, J. Bream, P. Duggal, J. Martinson, Steven Wolinsky, O. Martínez-Maza, C. Ramirez, B. Jamieson   +12 more
semanticscholar   +1 more source