Results 111 to 120 of about 1,709,620 (289)
Frontiers in PharmacologyObjective:Since 2016, China has successively implemented Accelerated Drug Marketing Registration Procedures (ADMRPs) for drugs, including Breakthrough Therapy Drug (BTD), Conditional Approval (CA), and Priority Review and Approval (PRA), which have ...
Yipeng Lan +7 more
doaj +1 more source
A review of avelumab in locally advanced and metastatic bladder cancer
Therapeutic Advances in Urology, 2019 Urothelial carcinoma remains a devastating disease with a poor prognosis. Though immune therapy with Bacillus Calmette–Guérin (BCG) has been used for localized bladder cancer for years, only immune-checkpoint blockade with antiprogrammed cell-death 1 ...
Arpit Rao, Manish R. Patel
doaj +1 more source
Case Reports in Oncology, 2020 Endometrial cancer is the only gynecological cancer that is rising in incidence and associated mortality worldwide. Although most cases are diagnosed as early stage disease, with chances of cure after primary surgical treatment, those with advanced or ...
Jesus Paula Carvalho +3 more
doaj +1 more source
Assessing the Impacts of the Prescription Drug User Fee Acts (PDUFA) on the FDA Approval Process [PDF]
Congress enacted and renewed the Prescription Drug User Fee Acts (PDUFA) in 1992, and renewed it in 1997 and 2002, mandating FDA performance goals in reviewing and acting on drug applications within specified time periods.
Adrian H. B. Gottschalk +3 more
core
An Added Dimension to the Faculty Role: The Accelerated Student [PDF]
, 2006 Nursing faculty work hard at helping students achieve academic success by utilizing a variety of support services. The question guiding this study is: Do accelerated and traditional BSN students have different characteristics or different valued support ...
Nelson, Deborah, Rauch, Lisa
core +1 more source
Sir John Adams: his legacy to the world of particle accelerators
, 2011 John Adams acquired an unrivalled reputation for his leading part in designing and constructing the Proton Synchrotron (PS) in CERN's early days. In 1968, and after several years heading a fusion laboratory in the UK, he came back to Geneva to pilot the ...
Wilson, E. J. N.
core +1 more source
High plasma leptin levels confer increased risk of atherosclerosis in women with systemic lupus erythematosus, and are associated with inflammatory oxidised lipids. [PDF]
, 2011 BackgroundPatients with systemic lupus erythematosus (SLE) are at increased risk of atherosclerosis, even after accounting for traditional risk factors.
Charles-Schoeman, Christina +14 more
core +2 more sources
FEBS Open Bio, EarlyView.Mitochondria‐associated membranes (MAMs) are contact sites between the endoplasmic reticulum and mitochondria that regulate calcium signaling, lipid metabolism, autophagy, and stress responses. This review outlines their molecular organization, roles in cellular homeostasis, and how dysfunction drives neurodegeneration, metabolic disease, cancer, and ...
Viet Bui +3 more
wiley +1 more source
Interplay between RNA‐protein interactions and RNA structures in gene regulation
FEBS Open Bio, EarlyView.Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko +2 more
wiley +1 more source
Frontiers in Pharmacology, 2019 Despite several innovative medicines gaining worldwide approval in recent years, there are still therapeutic areas for which unsatisfied therapeutic needs persist.
Cristina Scavone +5 more
doaj +1 more source