Results 141 to 150 of about 1,709,620 (289)

Pharmaceutical Patent Litigation Settlements: Implications for Competition and Innovation [PDF]

, 2010
Although brand-name pharmaceutical companies routinely procure patents on their innovative medications, such rights are not self-enforcing. Brand-name firms that wish to enforce their patents against generic competitors must commence litigation in the ...
Thomas, John R.
core   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Trends in and Determinants of Approval Lag for Anticancer Drugs in Japan and the US: Role of Multi‐Regional Trials and Concurrent Approvals

Clinical and Translational Science
Timely access to treatment for cancer patients requires the accelerated approval of new anticancer therapies. However, the lengthy pharmaceutical approval process in Japan has contributed to what is known as “drug lag.” Although recent efforts to promote
Hitoshi Kanno, Kotone Matsuyama
doaj   +1 more source

Collective Employee Representation and the Impact of Law: Initial Response to the Employment Relations Act 1999. [PDF]

Using data gathered primarily during interviews with managers and trade union officials, this article examines how trade unions and employers have reacted to the introduction of the statutory procedure for union recognition in the Employment Relations ...
C Pratten, S Deakin, S Oxenbridge, W Brown   +3 more
core  

Diffuse optical spectroscopic imaging reveals distinct early breast tumor hemodynamic responses to metronomic and maximum tolerated dose regimens. [PDF]

, 2020
BACKGROUND:Breast cancer patients with early-stage disease are increasingly administered neoadjuvant chemotherapy (NAC) to downstage their tumors prior to surgery. In this setting, approximately 31% of patients fail to respond to therapy.
Cabral, Howard, Jones, Eric, Ko, Naomi, Leproux, Anais, Mehta, Rita S, O'Sullivan, Thomas, Pera, Vivian, Peterson, Hannah M, Roblyer, Darren, Tabassum, Syeda, Tank, Anup, Tromberg, Bruce J   +11 more
core  

Institutional Policies on Artificial Intelligence in Higher Education: Frameworks and Best Practices for Faculty

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT This article explores institutional policies on artificial intelligence (AI) in higher education. As AI tools become increasingly utilized in academia—from research and teaching to assessment and student support—institutions face growing pressure to establish clear, ethical, and practical guidelines to help guide faculty.
Lauren Azevedo, Pedro Robles, Eric Best, Daniel J. Mallinson   +3 more
wiley   +1 more source

Continued cancer drug approvals in Japan and Europe after market withdrawal in the United States: A comparative study of accelerated approvals

Clinical and Translational Science
Regulatory authorities must balance ensuring evidence of efficacy and safety of new drugs. Various regulatory pathways, such as the accelerated approval program in the United States (US), allow authorities to quickly approve drugs for severely ill ...
Hayase Hakariya, Frank Moriarty, Akihiko Ozaki, Shai Mulinari, Hiroaki Saito, Tetsuya Tanimoto   +5 more
doaj   +1 more source

1706P Time to full approval of novel anticancer medicines granted accelerated approval and implications for reform of the accelerated approval pathway [PDF]

, 2023
Thomas J. Hwang, Consolación Moltó, M. Borrell Puy, Ariadna Tibau   +3 more
openalex   +1 more source

Practice Recommendations for Genetic Testing of Ataxias

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Over the past decade, significant advances in genetic testing for ataxia have improved diagnostic accuracy, informed clinical trial eligibility, guided treatment decisions, and enabled cascade testing of at‐risk relatives. While guidance exists for other neurogenetic conditions, there are no standardized guidelines on genetic ...
Sharan R. Srinivasan, Amy D. Mook, Michelle Rochman, Jin Yun Helen Chen, Weiyi Mu, George R. Wilmot, Liana S. Rosenthal, Wendy R. Uhlmann   +7 more
wiley   +1 more source

Monkeypox, smallpox, FDA, and accelerated approval of vaccines - A regulatory perspective. [PDF]

Vaccine, 2023
Sun WMD.
europepmc   +1 more source