Results 181 to 190 of about 159,613 (271)

Gleevec™ for the Treatment of Chronic Myelogenous Leukemia: U.S. Food and Drug Administration Regulatory Mechanisms, Accelerated Approval, and Orphan Drug Status [PDF]

, 2002
Martin H. Cohen, Marie L. Moses, Richard Pazdur   +2 more
openalex   +1 more source

Near‐Infrared Organic Photovoltaic Electrodes for Subretinal Neurostimulation

Advanced Functional Materials, EarlyView.
Organic photovoltaic electrodes based on the D18:Y6 blend enable precise and light‐controlled activation of retinal ganglion cells in a degenerating retina. NIR Light‐driven activation of retinal ganglion cells, tunable stimulation parameters, and biocompatibility with human retinal organoids highlight their potential for next‐generation prosthetics ...
Andrea Corna, Katarina Gugujonovic, Manuela Schiek, Alessandro Bellapianta, Paul Werginz, Amelie Ziller, Markus Clark Scharber, Ahmad Salti, Matthias Bolz, Mihai Irimia‐Vladu, Günther Zeck   +10 more
wiley   +1 more source

GeAl2‐2xFe2xO3(OH)4 Nanotubes: New Electrocatalyst for Oxygen Evolution Reaction

Advanced Functional Materials, EarlyView.
Fe‐doped imogolite nanotubes are synthesized via a one‐step hydrothermal method with varying Fe substitution ratios x. Structural and spectroscopic analyses confirm homogeneous Fe incorporation while preserving tubular shape. Optimal doping at x = 0.05 enhances optical absorption, narrows band gap, reduces charge transfer resistance, and significantly ...
Yassine Naciri, Jian Li, Wahid Ullah, Fabien Baron, Franck Bourdelle, Stéphan Rouzière, Claire Goldmann, Erik Elkaim, Thomas Bizien, Rachid Belkhou, Delphine Vantelon, Mohamed Nawfal Ghazzal, Erwan Paineau   +12 more
wiley   +1 more source

A Smart Bio‐Battery Facilitates Diabetic Bone Defect Repair Via Inducing Macrophage Reprogramming and Synergistically Modulating Bone Remodeling Coupling

Advanced Functional Materials, EarlyView.
This research presents a novel implantable bio‐battery, GF‐OsG, tailored for diabetic bone repair. GF‐OsG generates microcurrents in high‐glucose conditions to enhance vascularization, shift macrophages to the M2 phenotype, and regulate immune responses.
Nanning Lv, Haifu Sun, Wenxiang Tang, Yonggang Li, Zhonglai Qian, Lihui Hong, Chong Chen, Hongye Li, Jiaxiang Bai, Yusen Qiao, Mingming Liu   +10 more
wiley   +1 more source

Recent Trends in Medicaid Spending and Use of Drugs With US Food and Drug Administration Accelerated Approval.

JAMA Health Forum, 2021
Sachs RE, Gavulic KA, Donohue JM, Dusetzina SB.   +3 more
europepmc   +1 more source

Tracking the Dynamic and Interactive Metal Oxidation Changes in CoFe, CoNi, and NiFe Bimetallic Hydroxides for Electrocatalytic Oxygen Evolution

Advanced Functional Materials, EarlyView.
Operando hard X‐ray absorption spectroscopy is applied to track the dynamic and interactive metal oxidation changes in iron group bimetallic hydroxides under different chemical and electrochemical conditions. It shows that Co and Fe oxidation are relatively equal and synchronized in CoFeOxHy.
Jinzhen Huang, Adam H. Clark, Juliana Bruneli Falqueto, Erica D. Clinton, Kenneth Crossley, Thomas J. Schmidt, Emiliana Fabbri   +6 more
wiley   +1 more source

Regulatory and clinical consequences of negative confirmatory trials of accelerated approval cancer drugs: retrospective observational study.

BMJ, 2021
Gyawali B, Rome BN, Kesselheim AS.
europepmc   +1 more source

Table 1 from Real-World Clinical Oncology Outcomes Associated with the Accelerated Approval Pathway

Tu My To, Stacey Kowal, James D. Chambers, William B. Wong   +3 more
openalex   +1 more source

Programmable DNA‐Peptide Hybrid Nanostructures for Potent Neutralization of Multiple Influenza a Virus Subtypes

Advanced Functional Materials, EarlyView.
A multivalent antiviral platform based on honeycomb‐shaped DNA nanostructures (HC–Urumin) is developed to enhance the potency and breadth of the host defense peptide Urumin. Through spatially patterned trimeric presentation, HC–Urumin disrupts influenza A virus entry, improves cell viability, and reduces disease severity in vivo‐offering a modular and ...
Saurabh Umrao, Abhisek Dwivedy, Payton L. Haak, Dhanush Gandavadi, Laurie A. Rund, Chi Chen, Vineetha Mareddy, Lifeng Zhou, Jinwei Duan, Ying Fang, Andrew J. Steelman, Xing Wang   +11 more
wiley   +1 more source

Accelerating the approval of mpox vaccines based on lessons learnt from COVID-19 vaccines through the lens of regulatory science.

Shanshan Li, Xiaoyi Yu, Yifan Yao, Tianci Yao, Ming Xu   +4 more
openalex   +2 more sources