Results 211 to 220 of about 1,709,620 (289)

Advancing a managed care pharmacy research agenda: Generating real-world evidence to support US Food and Drug Administration Accelerated Approvals and improving benefit design to address health inequities

, 2022
Diana Brixner, J Couto, Karen Worley, Amber Small, Rupesh Panchal, Vyishali Dharbhamalla, Paula Eichenbrenner   +6 more
openalex   +2 more sources

High‐Performance Low‐Emissivity Paints Enabled by N‐Doped Poly(benzodifurandione) (n‐PBDF) for Energy‐Efficient Buildings

Advanced Functional Materials, EarlyView.
This study introduces a scalable and colored low‐emissivity (low‐e) paint achieved by spraying an ultrathin n‐doped poly(benzodifurandione) (n‐PBDF) coating onto various colored substrates. The low‐e paint enhances thermal regulation by reducing mid‐infrared thermal emissivity to 0.19, thereby stabilizing indoor temperatures across diverse climates ...
Xiaojie Liu, Won‐June Lee, Daniel William Carne, Yanpei Tian, Andrea Felicelli, Yue Lei, Joseph A. Romo, Liyan You, Zixin Xiong, Orlando Gabriel Rivera Gonzalez, Abdulrahman Aljwirah, Qiaoqiang Gan, Jianguo Mei, Xiulin Ruan   +13 more
wiley   +1 more source

Active Thermal Field Integration for Marangoni‐Driven Salt Rejection and Water Collection

Advanced Functional Materials, EarlyView.
A thermal gradient fabric (TGF) evaporator with an auxiliary active thermal field can simultaneously increase evaporation rates and achieve long‐term salt rejection. The auxiliary active thermal field is well integrated with solar energy to construct moderate, extensive, and circulating Marangoni flow for salt rejection.
Can Ge, Shuai Guo, Wei Li, Xunlong Zhang, Bin Chen, Xiao Feng, Shichang Yang, Duo Xu, Zhen Yu, Sai Kishore Ravi, Weilin Xu, Jian Fang, Swee Ching Tan   +12 more
wiley   +1 more source

Photothermal Hydrogel with Mn3O4 Nanoparticles Alleviates Intervertebral Disc Degeneration by Scavenging ROS and Regulating Extracellular Matrix Metabolism

Advanced Functional Materials, EarlyView.
The MPTT‐nanozyme‐hydrogel system (Mn3O4@ChS‐HA) provides a multifunctional therapeutic strategy for intervertebral disc degeneration (IVDD), effectively targeting oxidative stress and enhancing AF repair by restoring extracellular matrix (ECM) and redox homeostasis.
Yangyang Chen, Chan Xue, Feifei Ni, Binwu Hu, Miaoheng Yan, He Zhang, Yuxiang Hu, Xiaoyao Peng, Guangfang Li, Yu Han, Hongjian Liu, Zengwu Shao, Qin Wang, Yulong Wei   +13 more
wiley   +1 more source

Accelerated Approval and Breakthrough Therapy Designation: Oncology Drug Development on Speed?

, 2013
James C. Yao, Funda Meric‐Bernstam, J. Jack Lee, Sabine Eckhardt   +3 more
openalex   +1 more source

Evolving Platinum‐Copper Nanostructures for Enhanced Photothermal Therapy and Controlled Copper Release in Cancer Therapy

Advanced Functional Materials, EarlyView.
Platinum‐Copper bimetallic nanoparticles may evolve depending on their synthesis under tumor microenvironment conditions and play a dual role as chemotherapeutic agents after releasing Cu ions and as near infrared photothermal agents with the Pt‐rich remaining frames.
Jose I. Garcia‐Peiro, María Sancho‐Albero, Silvia Miguel, Andrea Mosseri, Felipe Hornos, Rafael Contreras‐Montoya, Jose L. Hueso, Jesus Santamaria   +7 more
wiley   +1 more source

Precise Quantification of Angiogenesis in 3D Biomaterials Using in Vitro CAM Models: Enhancing 3Rs in Research and Minimizing in Vivo Dependency

Advanced Functional Materials, EarlyView.
The study develops elastin–fibrin scaffolds and evaluates angiogenesis using the chorioallantoic membrane (CAM) model. Advanced imaging with confocal microscopy and Indocyanine Green dye enables precise 3D quantification of vascular networks. Findings demonstrate superior microvessel visualization compared to micro‐CT using Microfil and Optiray 350 ...
Ece Melis Er, Martha Patricia Pérez González, Beatriz Gil Garrido, Jasmine Ho, Hae‐Won Kim, Jonathan Campbell Knowles, Jia Hua, Ferdinand Lali, Prasad Sawadkar   +8 more
wiley   +1 more source

Oncology Accelerated Approval Confirmatory Trials: When a Failed Trial Is Not a Failed Drug. [PDF]

J Clin Oncol
Mehta GU, Pazdur R.
europepmc   +1 more source

Adalimumab‐Poloxamer Conjugate for Bio‐Better: Enhanced Stability and Function

Advanced Functional Materials, EarlyView.
Antibody‐polymer conjugates, particularly poloxamer conjugates, enhance antibody stability by improving tolerance to physicochemical stress and attenuating proteolysis by proteases. Furthermore, the higher affinity observed with poloxamer conjugation compared to standard PEGylation results in improved therapeutic efficacy in rheumatoid arthritis mouse ...
Jaewon Roh, Sanghee Lee, Soomin Cho, Kun Na   +3 more
wiley   +1 more source

Magnitude of clinical benefit in trials supporting US Food and Drug Administration (FDA) accelerated approval (AA) and European Medicines Agency (EMA) conditional marketing authorisation (CMA) and subsequent trials supporting conversion to full approval [PDF]

, 2018
M. Borrell Puy, C. Moltó Valiente, Kerstin Noëlle Vokinger, Thomas J. Hwang, Alberto Ocaña, Arnoud J. Templeton, Boštjan Šeruga, Ignasi Gich Saladich, Agustí Barnadas, Eitan Amir, Ariadna Tibau   +10 more
openalex   +1 more source