Results 71 to 80 of about 1,709,620 (289)
Cancer MedicineBackground Hundreds of cancer drugs are approved globally based on surrogate endpoint response rate (RR). However, the characteristics of RR‐based approvals remain unknown.
Ting Zhu, Jinjia Zhong, Yafang Huang
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PI3k Inhibitors in NHL and CLL: An Unfulfilled Promise
Blood and Lymphatic Cancer: Targets and Therapy, 2023 Naji Bou Zeid,1 Victor Yazbeck2 1Hôtel-Dieu de France Hospital, Saint Joseph University of Beirut, Beirut, Lebanon; 2Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USACorrespondence: Victor Yazbeck, Virginia Commonwealth University,
Bou Zeid N, Yazbeck V
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BMJ Open, 2021 Objectives Drug and biological products that treat rare, serious or life-threatening conditions can receive US Food and Drug Administration (FDA) orphan designation and expedited programme designations (accelerated approval, breakthrough therapy, fast ...
Dima M Qato +3 more
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Accelerated Approval of Aducanumab: Where Do We Stand Now?
The Annals of Pharmacotherapy, 2021 Aducanumab was approved by the Food and Drug Administration (FDA) in June 2021 to treat Alzheimer disease (AD). Its path to approval has been highly scrutinized, with many experts arguing that the FDA’s decision was premature.
Hedva Barenholtz Levy
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FEBS Letters, EarlyView.In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
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Biomarkers for immunotherapy in bladder cancer: a moving target
Journal for ImmunoTherapy of Cancer, 2017 Treatment options for metastatic urothelial carcinoma (mUC) remained relative unchanged over the last 30 years with combination chemotherapy as the mainstay of treatment.
David H. Aggen, Charles G. Drake
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Adaptive reuse of Libre software systems for supporting on-line collaboration [PDF]
, 2005 In this paper, the adaptive reuse of Plone; an open source content management system is described. In one instance, Plone has been used as the backbone of a collaboration and communication support infrastructure within a large research project.
Adams, Paul +3 more
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Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
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Trends in FDA drug approvals over last 2 decades: An observational study
Journal of Family Medicine and Primary Care, 2020 Introduction: The discovery of novel drugs is critical for pharmaceutical research and development as well as for patient treatment. Repurposing existing drugs that may have anticipated effects as potential candidate is one way to meet this important ...
Angelika Batta +2 more
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Molecular Oncology, EarlyView.The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song +11 more
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