Results 81 to 90 of about 519,139 (282)

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Accelerated Hazards Model: Method, Theory and Applications [PDF]

, 2002
In an accelerated hazards model, the hazard functions of a failure time are related through the time scale-change, which is often a function of covariates and associated parameters.
Chen, Ying Qing, Jewell, Nicholas P., Yang, Jingrong   +2 more
core   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Instrumental variable estimation of treatment effects for duration outcomes [PDF]

, 2007
In this article we propose and implement an instrumental variable estimation procedure to obtain treatment effects on duration outcomes. The method can handle the typical complications that arise with duration data of time-varying treatment and ...
Bijwaard, G.E. (Govert)
core   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

Joint Modeling of Linear Degradation and Multiple Dependent Competing Risks Data under a Step-Stress Accelerated Degradation Test

Journal of Statistical Theory and Applications (JSTA), 2018
The step-stress accelerated degradation test (SSADT) is one of the most commonly used time-dependent types of stress loading tests that enables a shorter test duration. This test is more economical and flexible compared to accelerated degradation test or
Somayeh Mireh, Ahmad Khodadadi, Firoozeh Haghighi   +2 more
doaj   +1 more source

Testing Inference in Accelerated Failure Time Models

International Journal of Statistics and Probability, 2014
We address the issue of performing hypothesis testing in accelerated failure time models for non-censored and censored samples. The performances of the likelihood ratio test and a recently proposed test, the gradient test, are compared through simulation.
Medeiros, Francisco M. C., Silva-Júnior, Antônio H. M. da, Valença, Dione M., Ferrari, Silvia L. P.   +3 more
openaire   +3 more sources

The McCance Brain Care Score and Mortality: Evidence From a Large‐Scale Population‐Based Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives This study aimed to examine the relationship between the McCance Brain Care Score (BCS) and mortality in the general population. Methods We conducted a prospective, population‐based cohort study using data from the UK Biobank. Participants with complete data enabling calculation of BCS and full mortality information were included ...
Zhiqiang Xu, Xiaoxiao Wang, Nan Li
wiley   +1 more source

Survival parametric modeling for patients with heart failure based on Kernel learning

BMC Medical Research Methodology
Time-to-event data are very common in medical applications. Regression models have been developed on such data especially in the field of survival analysis.
Maryam Montaseri, Mansour Rezaei, Armin Khayati, Shayan Mostafaei, Mohammad Taheri   +4 more
doaj   +1 more source

Modeling dynamic effects of promotion on interpurchase times [PDF]

In this paper we put forward a duration model to analyze the dynamic effects of marketing-mix variables on interpurchase times. We extend the accelerated failure-time model with an autoregressive structure.
Fok, D., Franses, Ph.H.B.F., Paap, R.
core   +1 more source