Results 41 to 50 of about 221,595 (265)
Mathematics, 2023 In this paper, estimations of the parameter and acceleration factor of the Burr–Hatke exponential distribution in partially accelerated life tests under progressively type II censoring are investigated. By using typical maximum likelihood methods and the
Xuanyi Gao, Wenhao Gui
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
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Design and Implementation of Trial Test for Accelerated Life Test
机车电传动, 2019 In order to predict the remaining life of electronic products of rail transit, trial test of ccelerated life test (ALT) was designed and implemented for designing scheme of ALT effectively.
Yuxiong PAN, Guifa ZHOU, Xu WANG
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Chinese Journal of Mechanical Engineering, 2018 Constant stress accelerated life tests (ALTs) can be applied to obtain a high estimation accuracy of reliability measurements, but these are time-consuming tests. Progressive stress ALTs can yield failures more quickly but cannot guarantee the estimation
Wen-Hua Chen +4 more
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FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
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Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
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Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
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Jurnal Kimia Sains dan Aplikasi, 2020 Stekurmin MD is a syrup preparation formulated from the extract of Stevia rebaudiana leaves, temu lawak (Curcuma zanthorrhiza), and honey. One of the active compounds in Stekurmin MD products is phenolic and flavonoid compounds in which the active ...
Yohanes Martono +2 more
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Degradation Characteristics and Reliability Assessment of 1310 nm VCSEL for Microwave Photonic Link
Applied Sciences, 2022 The long-term reliability of the commercially available vertical-cavity surface-emitting laser (VCSEL) at 1310 nm wavelength is investigated. To do so, a high current accelerated life test is used to evaluate the 1310 nm VCSEL reliability.
Wenyuan Liao +7 more
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Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
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