Results 61 to 70 of about 247,169 (216)

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Análise dos efeitos das incertezas nas estimativas de tempos de falha de produtos via ensaios acelerados Uncertainty effect analysis on time to failure estimates through accelerated life tests

Production, 2007
As empresas do setor industrial têm hoje o desafio de lançar rapidamente produtos mantendo, entretanto, sua confiabilidade em níveis progressivamente crescentes.
Maria Célia de Oliveira Papa, Alvaro J. Abackerli, Paulo Augusto Cauchick Miguel   +2 more
doaj   +1 more source

Inferences for Stress-Strength Reliability Model in the Presence of Partially Accelerated Life Test to Its Strength Variable. [PDF]

Comput Intell Neurosci, 2022
El-Sagheer RM, Tolba AH, Jawa TM, Sayed-Ahmed N, Sayed-Ahmed N.   +4 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Inferences for Exponentiated Gamma Constant-Stress Partially Accelerated Life Test Model Based on Generalized Type-I Hybrid Censored Data. [PDF]

Comput Intell Neurosci, 2021
Rabie A, Ahmad AA, Barry TS, Aljohani HM, Alfaer NM, Alghamdi AS.   +5 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

The research on accelerated life test reliability prediction method for electronic tags

Dianzi Jishu Yingyong
With the continuous development of microelectronic components design capability and process technology, the reliability and life of the device is increasing.
Fu Lili, Dong Xuehe, Niu Changsheng, Liang Zhaoqing, Bai Xuesong, Cui Lan   +5 more
doaj   +1 more source