Results 81 to 90 of about 1,219,708 (305)

Inferences for Exponentiated Gamma Constant-Stress Partially Accelerated Life Test Model Based on Generalized Type-I Hybrid Censored Data. [PDF]

Comput Intell Neurosci, 2021
Rabie A, Ahmad AA, Barry TS, Aljohani HM, Alfaer NM, Alghamdi AS.   +5 more
europepmc   +1 more source

Sequential Bayesian Design for Accelerated Life Tests

Technometrics, 2018
Most of the recently developed methods on optimum planning for accelerated life tests (ALT) involve “guessing” values of parameters to be estimated, and substituting such guesses in the proposed solution to obtain the final testing plan. In reality, such guesses may be very different from true values of the parameters, leading to inefficient test plans.
I-Chen Lee, Yili Hong 0001, Sheng-Tsaing Tseng, Tirthankar Dasgupta   +3 more
openaire   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

A Study on the Storage Reliability of LSINS Based on Step-stress Accelerated Life Test

MATEC Web of Conferences, 2015
Based on the step-stress accelerated life test and the laser strap-down inertial navigation system, this paper studies the accelerated life model and the test method, provides the likelihood function, the likelihood equation and the two-order derivative ...
Teng Fei, Liu Yuanyuan, Huang Baosheng
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

The research on accelerated life test reliability prediction method for electronic tags

Dianzi Jishu Yingyong
With the continuous development of microelectronic components design capability and process technology, the reliability and life of the device is increasing.
Fu Lili, Dong Xuehe, Niu Changsheng, Liang Zhaoqing, Bai Xuesong, Cui Lan   +5 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Análise dos efeitos das incertezas nas estimativas de tempos de falha de produtos via ensaios acelerados Uncertainty effect analysis on time to failure estimates through accelerated life tests

Production, 2007
As empresas do setor industrial têm hoje o desafio de lançar rapidamente produtos mantendo, entretanto, sua confiabilidade em níveis progressivamente crescentes.
Maria Célia de Oliveira Papa, Alvaro J. Abackerli, Paulo Augusto Cauchick Miguel   +2 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source