Results 71 to 80 of about 1,486,900 (338)

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Ancilla-Mediated Higher Entanglement as T-Duality, a Categorial Conjecture

Quantum Reports
In this article, I start with a general presentation of the ideas behind sigma models and higher gauge theories and introduce the possibility of a higher entanglement structure.
Andrei T. Patrascu
doaj   +1 more source

Channel Prediction Based on BP Neural Network for Backscatter Communication Networks

Sensors, 2020
Backscatter communication networks are receiving a lot of attention thanks to the application of ultra-low power sensors. Because of the large amount of sensor data, increasing network throughput becomes a key issue, so rate adaption based on channel ...
Jumin Zhao, Hao Tian, Deng-ao Li
doaj   +1 more source

Longitudinal Dynamic versus Kinematic Models for Car-Following Control Using Deep Reinforcement Learning

, 2019
The majority of current studies on autonomous vehicle control via deep reinforcement learning (DRL) utilize point-mass kinematic models, neglecting vehicle dynamics which includes acceleration delay and acceleration command dynamics.
Azad, Nasser L., Lin, Yuan, McPhee, John
core   +1 more source

Beyond self-acceleration: Force- and fluid-acceleration

Physics Letters B, 2020
The notion of self-acceleration has been introduced as a convenient way to theoretically distinguish cosmological models in which acceleration is due to modified gravity from those in which it is due to the properties of matter or fields. In this paper we review the concept of self-acceleration as given, for example, by [1], and highlight two problems.
Amendola, Luca, Pettorino, Valeria
openaire   +5 more sources

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Absence of Electron Surfing Acceleration in a Two-Dimensional Simulation

, 2007
Electron acceleration in high Mach number perpendicular shocks is investigated through two-dimensional electrostatic particle-in-cell (PIC) simulation.
Bell A. R., Fumio Takahara, Papadopoulos K., Yutaka Ohira   +3 more
core   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Multifaceted Assessment of Responsible Use and Bias in Language Models for Education

Computers
Large language models (LLMs) are increasingly being utilized to develop tools and services in various domains, including education. However, due to the nature of the training data, these models are susceptible to inherent social or cognitive biases ...
Ishrat Ahmed, Wenxing Liu, Rod D. Roscoe, Elizabeth Reilley, Danielle S. McNamara   +4 more
doaj   +1 more source