Results 71 to 80 of about 409,460 (298)

Multifaceted Assessment of Responsible Use and Bias in Language Models for Education

Computers
Large language models (LLMs) are increasingly being utilized to develop tools and services in various domains, including education. However, due to the nature of the training data, these models are susceptible to inherent social or cognitive biases ...
Ishrat Ahmed, Wenxing Liu, Rod D. Roscoe, Elizabeth Reilley, Danielle S. McNamara   +4 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Differences in respiratory wheezing between current exclusive e-cigarette users, current exclusive cigarette smokers, and never users of either product: findings from a population-based study

Harm Reduction Journal
Background E-cigarettes have emerged as an alternative to combustible cigarettes, yet their comparative impact on respiratory symptoms remains uncertain.
Yusuff Adebayo Adebisi, Najim Z. Alshahrani, Lucia Spicuzza, Francesco Pennisi, Giulio Geraci, Giulio Giacono Cantone, Venera Tomaselli, Riccardo Polosa   +7 more
doaj   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Accelerating beams [PDF]

Optics Letters, 2009
We demonstrate that any two-dimensional accelerating beam can be described in a canonical form in Fourier space. In particular, we demonstrate that there is a one-to-one correspondence between complex functions in the real line (the line spectrum) and accelerating beams.
openaire   +3 more sources

Beyond carbon emissions reductions: Examining the co-benefits of industrial decarbonisation in the United Kingdom

Renewable and Sustainable Energy Transition
Industrial decarbonisation reduces greenhouse gases emissions and also deliver broader economic and social gains. We synthesise co-benefits of decarbonising energy-intensive industries in the United Kingdom by combining a scoping review with evidence ...
Abbas AbdulRafiu, Benjamin K. Sovacool, Marc Hudson, M. Mercedes Maroto-Valer, Clare Howard   +4 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Linear Accelerators

, 2013
35 pages, contribution to the CAS - CERN Accelerator School: Advanced Accelerator Physics Course, Trondheim, Norway, 18-29 Aug 2013.
openaire   +3 more sources

Explaining Deep Learning Models for Age-related Gait Classification based on time series acceleration [PDF]

, 2023
Xiaoping Zheng, Bert Otten, Michiel F. Reneman, Claudine J. C. Lamoth   +3 more
openalex   +1 more source