Results 71 to 80 of about 337,169 (269)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Trailblazers in STEM: a document analysis of the accomplishments of Louis Stokes Alliances for Minority Participation alumni

Frontiers in Education
The National Science Foundation (NSF) Louis Stokes Alliance for Minority Participation (LSAMP) has a > 30-year history of providing high impact educational experiences to undergraduates and graduate students of color in science, technology ...
Dominique Smart Graham, Dominique Smart Graham, Meli'sa S. Crawford, Meli'sa S. Crawford, Meli'sa S. Crawford, Ana M. Chicas-Mosier, Ana M. Chicas-Mosier   +6 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Multifaceted Assessment of Responsible Use and Bias in Language Models for Education

Computers
Large language models (LLMs) are increasingly being utilized to develop tools and services in various domains, including education. However, due to the nature of the training data, these models are susceptible to inherent social or cognitive biases ...
Ishrat Ahmed, Wenxing Liu, Rod D. Roscoe, Elizabeth Reilley, Danielle S. McNamara   +4 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Determination of residual alkyl iodides and alkyl bromides as their corresponding alkyl chlorides in drug substances by headspace GC-FID

Heliyon
Primary and secondary alkyl iodides and primary alkyl bromides were quickly and conveniently converted into their corresponding alkyl chlorides via SN2 halide-halide substitution.
Brian T. Zielke II
doaj   +1 more source

Accelerator virtualization [PDF]

Concurrency and Computation: Practice and Experience, 2021
Carlos Reaño, Federico Silla, Blesson Varghese   +2 more
openaire   +2 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Differences in respiratory wheezing between current exclusive e-cigarette users, current exclusive cigarette smokers, and never users of either product: findings from a population-based study

Harm Reduction Journal
Background E-cigarettes have emerged as an alternative to combustible cigarettes, yet their comparative impact on respiratory symptoms remains uncertain.
Yusuff Adebayo Adebisi, Najim Z. Alshahrani, Lucia Spicuzza, Francesco Pennisi, Giulio Geraci, Giulio Giacono Cantone, Venera Tomaselli, Riccardo Polosa   +7 more
doaj   +1 more source

Beyond carbon emissions reductions: Examining the co-benefits of industrial decarbonisation in the United Kingdom

Renewable and Sustainable Energy Transition
Industrial decarbonisation reduces greenhouse gases emissions and also deliver broader economic and social gains. We synthesise co-benefits of decarbonising energy-intensive industries in the United Kingdom by combining a scoping review with evidence ...
Abbas AbdulRafiu, Benjamin K. Sovacool, Marc Hudson, M. Mercedes Maroto-Valer, Clare Howard   +4 more
doaj   +1 more source