Results 71 to 80 of about 671,164 (293)

Piezoelectric Accelerator [PDF]

open access: yesScientific Reports, 2018
AbstractHere we propose the conception of small-size piezoelectric accelerator of charged particles that operates due to the piezoelectric effect at varying mechanical force applied to piezoelectrics in vacuum. The accelerating voltage and the energy of accelerated particles are estimated.
O. O. Ivashchuk   +6 more
openaire   +2 more sources

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Reverse spin bias: preliminary observations of reporting bias in medical systematic reviews

open access: yesResearch Integrity and Peer Review
Background While conducting an umbrella review of e-cigarettes for smoking cessation, we observed that in many instances, systematic review authors reported findings favorable to the treatment, yet they declined to recommend it or recommended against it ...
Renée O’Leary   +2 more
doaj   +1 more source

Accelerating expansion [PDF]

open access: yesRNA, 2015
This article considers the state of the RNA field and how it has progressed over a time span of decades.
openaire   +3 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

Validation of ERMES 20.0 finite element code for MAST Upgrade O-X mode conversion [PDF]

open access: yesEPJ Web of Conferences
This study presents the validation of the frequency-domain finite element code ERMES 20.0, benchmarked against Finite Difference Time Domain (FDTD) solvers.
Otin Ruben   +4 more
doaj   +1 more source

Timescales for detecting a significant acceleration in sea level rise [PDF]

open access: yes, 2014
There is observational evidence that global sea level is rising and there is concern that the rate of rise will increase, significantly threatening coastal communities.
Pattiaratchi, Charitha B.   +9 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

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