Results 81 to 90 of about 1,501,755 (279)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Intersection of Immunity, Metabolism, and Muscle Regeneration in an Autoimmune‐Prone MRL Mouse Model

Advanced Science
Due to the limited capacity of mammals to regenerate complex tissues, researchers have worked to understand the mechanisms of tissue regeneration in organisms that maintain that capacity.
Tran B. Ngo, Aditya Josyula, Sabrina DeStefano, Daphna Fertil, Mondreakest Faust, Ravi Lokwani, Kaitlyn Sadtler   +6 more
doaj   +1 more source

Ancilla-Mediated Higher Entanglement as T-Duality, a Categorial Conjecture

Quantum Reports
In this article, I start with a general presentation of the ideas behind sigma models and higher gauge theories and introduce the possibility of a higher entanglement structure.
Andrei T. Patrascu
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Improved Acceleration of the GPU Fourier Domain Acceleration Search Algorithm

, 2017
We present an improvement of our implementation of the Correlation Technique for the Fourier Domain Acceleration Search (FDAS) algorithm on Graphics Processor Units (GPUs) (Dimoudi & Armour 2015; Dimoudi et al. 2017).
Adámek, Karel, Armour, Wesley, Dimoudi, Sofia, Giles, Mike   +3 more
core  

Fast Shocks From Magnetic Reconnection Outflows

, 2011
Magnetic reconnection is commonly perceived to drive flow and particle acceleration in flares of solar, stellar, and astrophysical disk coronae but the relative roles of different acceleration mecha- nisms in a given reconnection environment are not well
Chuang Ren, Eric G. Blackman, Jared C. Workman, Romanova M. M., Tandberg-Hanssen E.   +4 more
core   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The spectral evolution of impulsive solar X-ray flares. II.Comparison of observations with models

, 2005
We study the evolution of the spectral index and the normalization (flux) of the non-thermal component of the electron spectra observed by RHESSI during 24 solar hard X-ray flares.
A. O. Benz, Benz, Brown, Brown, Brown, Gan, Grigis, Holman, Lu, Miller, Miller, P. C. Grigis, Parks, Petrosian, Sweet   +14 more
core   +1 more source

Trailblazers in STEM: a document analysis of the accomplishments of Louis Stokes Alliances for Minority Participation alumni

Frontiers in Education
The National Science Foundation (NSF) Louis Stokes Alliance for Minority Participation (LSAMP) has a > 30-year history of providing high impact educational experiences to undergraduates and graduate students of color in science, technology ...
Dominique Smart Graham, Dominique Smart Graham, Meli'sa S. Crawford, Meli'sa S. Crawford, Meli'sa S. Crawford, Ana M. Chicas-Mosier, Ana M. Chicas-Mosier   +6 more
doaj   +1 more source