Results 41 to 50 of about 264,692 (309)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Preliminary analysis of seismic performance of a shear wall structure in Qinghai Maduo M7.4 earthquake

地球与行星物理论评, 2022
In this paper, the measured acceleration of Dawu station of the M7.4 earthquake in Maduo County, Qinghai Province on May 22, 2021 and the acceleration at Yematan bridge simulated by our research group with the empirical Green's function method are ...
Bo Zhang, Xueliang Chen, Lijun Qiu, Lingyu Liang   +3 more
doaj   +1 more source

Some problems in the application of spectrum techniques to strong-motion earthquake analysis [PDF]

, 1962
A comparison of analog and digital computation of strong-motion earthquake response spectra is made, and it is shown that the preference as to method will depend mainly on availability of computing equipment.
Hudson, D. E.
core   +1 more source

Seismic reliability assessment of classical columns subjected to near-fault ground motions [PDF]

, 2013
A methodology for the performance-based seismic risk assessment of classical columns is presented. Despite their apparent instability, classical columns are, in general, earthquake resistant, as proven from the fact that many classical monuments have ...
Fragiadakis, Michalis, Psycharis, Ioannis, Stefanou, Ioannis   +2 more
core   +5 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Design Spectrum Analysis in NASTRAN [PDF]

, 1984
The utility of Design Spectrum Analysis is to give a mode by mode characterization of the behavior of a design under a given loading. The theory of design spectrum is discussed after operations are explained.
Butler, T. G.
core   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Lamb Shift of Unruh Detector Levels

, 2005
We argue that the energy levels of an Unruh detector experience an effect similar to the Lamb shift in Quantum Electrodynamics. As a consequence, the spectrum of energy levels in a curved background is different from that in flat space.
Audretsch J, Björn Garbrecht, Garbrecht B, Gradshteyn I S, Hawking S W, Higuchi A, Prokopec T, Prokopec T, Tomislav Prokopec, Watson G N   +9 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Research on the Influence of the Target Spectrum and Amplitude Scaling Method on the Dynamic Time History Analysis Results of a High-Rise Building Structure

Buildings
This study addresses the critical need for region-specific ground motion selection methods in the Xi’an area by proposing a novel Peak Ground Acceleration (PGA)-based target spectrum, developed through the relationship between PGA and response spectrum ...
Jianhui Niu, Yupeng Xie, Penggang Tian, Kai Wang, Zhiheng Tian, Ergang Xiong, Feng Yue   +6 more
doaj   +1 more source