Results 41 to 50 of about 2,234,030 (304)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Innovative applications of genetic algorithms to problems in accelerator physics

Physical Review Special Topics. Accelerators and Beams, 2013
The genetic algorithm (GA) is a powerful technique that implements the principles nature uses in biological evolution to optimize a multidimensional nonlinear problem.
Alicia Hofler, Balša Terzić, Matthew Kramer, Anton Zvezdin, Vasiliy Morozov, Yves Roblin, Fanglei Lin, Colin Jarvis   +7 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Highlights of Accelerator Activities in France on behalf of the Accelerator Division of the French Physics Society [PDF]

, 2010
MOPEA048International audienceThe French Physics Society is an association the purpose of which is to promote physics and physicists. In this context, the accelerator physics and associated technology division is in charge of the promotion of accelerator
Chautard, F., Lemaire, J.-L., Denard, J., Maccioni, P., Ausset, P., Baylac, M.A., Kircher, F., Roux, R., Revol, J.-L., Cros, B.   +9 more
core   +2 more sources

Explainable physics-based constraints on reinforcement learning for accelerator optimization

Machine Learning: Science and Technology
We present a reinforcement learning (RL) framework for optimizing particle accelerator experiments that builds explainable physics-based constraints on agent behavior.
Jonathan Colen, Malachi Schram, Kishansingh Rajput, Armen Kasparian   +3 more
doaj   +1 more source

High energy density physics with intense ion beams

Matter and Radiation at Extremes, 2016
We review the development of High Energy Density Physics (HEDP) with intense heavy ion beams as a tool to induce extreme states of matter. The development of this field connects intimately to the advances in accelerator physics and technology.
Boris Yu. Sharkov, Dieter H.H. Hoffmann, Alexander A. Golubev, Yongtao Zhao   +3 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Accelerator Physics Coordinate Conventions [PDF]

, 1993
This document is about the establishment of unique nominal coordinate conventions inside the RHIC accelerator physics RAP(group)
Peggs, S., MacKay, W.
core   +1 more source

Physics design of an accelerator for an accelerator-driven subcritical system

Physical Review Special Topics. Accelerators and Beams, 2013
An accelerator-driven subcritical system (ADS) program was launched in China in 2011, which aims to design and build an ADS demonstration facility with the capability of more than 1000 MW thermal power in multiple phases lasting about 20 years.
Zhihui Li, Peng Cheng, Huiping Geng, Zhen Guo, Yuan He, Cai Meng, Huafu Ouyang, Shilun Pei, Biao Sun, Jilei Sun, Jingyu Tang, Fang Yan, Yao Yang, Chuang Zhang, Zheng Yang   +14 more
doaj   +1 more source

Topics in the Physics of Particle Accelerators [PDF]

, 1985
High energy physics, perhaps more than any other branch of science, is driven by technology. It is not the development of theory, or consideration of what measurements to make, which are the driving elements in our science. Rather it is the development of new technology which is the pacing item.
openaire   +2 more sources