Results 61 to 70 of about 1,231,948 (375)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Tevatron Collider Program - Physics, Results, Future? [PDF]

, 2011
An overview of more than 25 years of the Tevatron Collider program at Fermi National Accelerator Laboratory in Batavia, near Chicago, Illinois, USA, is presented.
Sliwa, Krzysztof
core  

Physics Opportunities with the FCC-hh Injectors [PDF]

, 2017
In this chapter we explore a few examples of physics opportunities using the existing chain of accelerators at CERN, including potential upgrades. In this context the LHC ring is also considered as a part of the injector system.
Bai, M., Ball, A., Batell, B., Bowcock, T., Cavoto, G., Ceccucci, A., Chrzaszcz, M., Goddard, B., Golutvin, A., Herr, W., Isidori, G., Jowett, J., Moulson, M., Nakada, T., Rojo, J., Semertzidis, Y., Teubert, F.   +16 more
core   +3 more sources

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Symmetry, Hamiltonian Problems and Wavelets in Accelerator Physics

, 1999
In this paper we consider applications of methods from wavelet analysis to nonlinear dynamical problems related to accelerator physics. In our approach we take into account underlying algebraical, geometrical and topological structures of corresponding ...
Fedorova, Antonina N., Parsa, Zohreh, Zeitlin, Michael G.   +2 more
core   +1 more source

Emittance preservation in a plasma-wakefield accelerator [PDF]

Nature Communications
Radio-frequency particle accelerators are engines of discovery, powering high-energy physics and photon science, but are also large and expensive due to their limited accelerating fields.
C. Lindstrøm, J. Beinortaitė, J. Björklund Svensson, L. Boulton, J. Chappell, S. Diederichs, B. Foster, J. Garland, P. González Caminal, G. Loisch, F. Peña, S. Schröder, M. Th'evenet, S. Wesch, M. Wing, J. C. Wood, R. D’Arcy, J. Osterhoff   +17 more
semanticscholar   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Applying Bayesian inference and deterministic anisotropy to retrieve the molecular structure ∣Ψ(R)∣2 distribution from gas-phase diffraction experiments

Communications Physics, 2023
Currently, our general approach to retrieving molecular structures from ultrafast gas-phase diffraction heavily relies on complex ab initio electronic or vibrational excited state simulations to make conclusive interpretations.
Kareem Hegazy, Varun Makhija, Phil Bucksbaum, Jeff Corbett, James Cryan, Nick Hartmann, Markus Ilchen, Keith Jobe, Renkai Li, Igor Makasyuk, Xiaozhe Shen, Xijie Wang, Stephen Weathersby, Jie Yang, Ryan Coffee   +14 more
doaj   +1 more source

Beam-Beam Effects

, 2016
One of the most severe limitations in high-intensity particle colliders is the beam-beam interaction, i.e. the perturbation of the beams as they cross the opposing beams.
Herr, W., Pieloni, T.
core   +1 more source

The High-Luminosity upgrade of the LHC: Physics and Technology Challenges for the Accelerator and the Experiments

, 2016
In the second phase of the LHC physics program, the accelerator will provide an additional integrated luminosity of about 2500/fb over 10 years of operation to the general purpose detectors ATLAS and CMS. This will substantially enlarge the mass reach in
B. Schmidt
semanticscholar   +1 more source