Results 111 to 120 of about 173,486 (295)

Accelerating beams [PDF]

open access: yesOptics Letters, 2009
We demonstrate that any two-dimensional accelerating beam can be described in a canonical form in Fourier space. In particular, we demonstrate that there is a one-to-one correspondence between complex functions in the real line (the line spectrum) and accelerating beams.
openaire   +3 more sources

GPUs as Storage System Accelerators

open access: yes, 2012
Massively multicore processors, such as Graphics Processing Units (GPUs), provide, at a comparable price, a one order of magnitude higher peak performance than traditional CPUs.
Al-Kiswany, Samer   +2 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Probing the Top Quark Flavour-Changing Neutral Current at a Future Electron-Positron Collider

open access: yesAdvances in High Energy Physics, 2014
We present a study to examine the sensitivity of a future e-e+ collider to the anomalous top flavour-changing neutral current (FCNC) to the gluon. To separate signal from background a multivariate analysis is performed on top quark pair and background ...
Hoda Hesari   +3 more
doaj   +1 more source

RF power generation

open access: yes, 2011
This paper reviews the main types of r.f. power amplifiers which are, or may be, used for particle accelerators. It covers solid-state devices, tetrodes, inductive output tubes, klystrons, magnetrons, and gyrotrons with power outputs greater than 10 kW c.
Carter, R. G.
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Charged current weak electroproduction of Delta resonance

open access: yes, 1997
We study the weak production of $\Delta$ (i.e. $e^{-} + p \to \Delta^{0}+ \nu_{e}$ and $e^{+} + p \to \Delta^{++} + \bar{\nu}_{e}$) in the intermediate energy range corresponding to the Mainz and TJNAF electron accelerators.
A. J. Buchmann   +43 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Home - About - Disclaimer - Privacy