Results 191 to 200 of about 245,739 (312)

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

A Codesign Framework for the Development of Next Generation Wearable Computing Systems. [PDF]

Sensors (Basel)
Porreca F, Frustaci F, Gravina R.
europepmc   +1 more source

Task Group 142 report: quality assurance of medical accelerators.

Medical Physics (Lancaster), 2009
E. Klein, J. Hanley, J. Bayouth, F. Yin, W. Simon, S. Dresser, C. Serago, F. Aguirre, Lijun Ma, B. Arjomandy, Chihray R Liu, C. Sandin, T. Holmes   +12 more
semanticscholar   +1 more source

Arterial Spin‐Labeling MRI at the Cortical‐CSF Interface: A Novel Biomarker in Alzheimer Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background/Objective Arterial spin‐labeling (ASL) MRI can measure perfusion signal adjacent to CSF spaces and may provide information regarding CSF‐adjacent water transport physiology. We developed an automated pipeline to extract cortical‐CSF interface (IF) perfusion for comparison between Alzheimer disease (AD) and cognitively normal ...
Mona Asghariahmadabad, Pouya Metanat, Michael Thomas, Luke W. Bonham, Tyson Lam, Mehmet Kurt, Hong Nguyen, Tara Ellingson, Mauro Zucchelli, Stefano Casagranda, Quin Lu, Andreas M. Rauschecker, Leo Sugrue, Luis E. Savastano, Christopher P. Hess, Kamalini Ranasinghe, S. Andrew Josephson, Bruce L. Miller, Jennifer S. Yokoyama, Gil D. Rabinovici, Peter A. Ljubenkov, Lawren VandeVrede, Kambiz Nael   +22 more
wiley   +1 more source

Pulse‑level characterization of low monitor unit deliveries on a modern linear accelerator using a plastic scintillation detector. [PDF]

J Appl Clin Med Phys
White AJ, Yadav P, Das IJ, Khan AU.
europepmc   +1 more source

The Price of Precision: A Critical Review of Molecular Diagnostics in Glioma, From Guidelines to Global Disparities

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Gliomas have undergone a profound redefinition over the past decade, transitioning from morphology‐based entities to biologically coherent diseases defined by molecular alterations. The 2021 WHO Classification of Tumors of the Central Nervous System and its 2022 update formalize this shift, establishing integrated diagnosis as the global ...
Maria Guarnaccia, Sebastiano Cavallaro
wiley   +1 more source

Review of large YOLOv8 and RT-DETR energy efficiency on edge devices for real-time detection. [PDF]

Sci Rep
Suchý I, Turčaník M.
europepmc   +1 more source

White Matter and Perivascular Imaging Changes in Alzheimer's Disease and Cerebral Amyloid Angiopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Peak‐width of skeletonized mean diffusivity (PSMD) and diffusion tensor imaging–analysis along the perivascular space (DTI‐ALPS), reflecting white matter integrity and glymphatic function, are altered in Alzheimer's disease (AD).
Debina Laishram, Guangwei Du, Sangam Kanekar, Nandakumar Nagaraja   +3 more
wiley   +1 more source

Advances in proton therapy technology and global clinical applications. [PDF]

Front Oncol
Zhang Q, Yang W, Tan L, Guo X, Wang T, Zhu P, Jing Z, Ma L, Hou J.   +8 more
europepmc   +1 more source

Prevalence of Contact Allergy to Rubber Accelerators From the European Baseline Series in Dermatitis Patients: A Systematic Review and Meta-Analysis. [PDF]

Contact Dermatitis
Isufi D, Kursawe Larsen C, Jensen MB, Karimian K, Zachariae C, Schwensen JFB, Alinaghi F, Johansen JD.   +7 more
europepmc   +1 more source