Results 71 to 80 of about 19,883 (299)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The formation and accentuation of Education terms. [PDF]

open access: yes, 2012
The bachelor thesis analyzes 1077 terms of education which were selected from Encyclopaedic Dictionary of Education (Enciklopedinis edukologijos žodynas) by L. Jovaiša (2007).
Kavaliauskaitė, Aušra,
core  

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

open access: yesFEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise   +5 more
wiley   +1 more source

Accentuation [PDF]

open access: yes, 2014
The accent marks in modern editions of Ancient Greek texts primarily reflect the accentual system of an educated register of the Koine of the early 2nd c. BCE. In this system, phonological, morphological, and lexical factors conspire to associate a pitch
Gunkel, Dieter
core   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

open access: yesFEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos   +9 more
wiley   +1 more source

Issues in Balto-Slavic accentology [PDF]

open access: yes, 2010
After the very well-organized Leiden conference for which we must be grateful to Tijmen Pronk, it seems appropriate for me to review some of the papers, as I did after the previous conferences in Zagreb and Copenhagen. The aim of this review is merely to
Kortlandt, Frederik H. H.
core  

Smaller is better: nanobodies meet NMR

open access: yesFEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Patterns of accentuation in the classical style ... [PDF]

open access: yes, 1984
This document concerns itself with aspects of late eighteenth-century performance practice, most notably, accentuation. The aspect of eighteenth-century style that is often neglected in twentieth-century performances is the use of proper accentuation ...
Trott, Donald Lee,
core  

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

open access: yesFEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Accentuating the Negative?

open access: yesMethodology, 2010
Survey research on political efficacy is longstanding. In a number of countries efficacy has been measured using batteries of negatively worded “agree-disagree” statements. In this paper, we investigate the measurement properties of the Canadian variant of this traditional battery and compare its performance with an alternative, positively worded ...
Harold D. Clarke   +2 more
openaire   +1 more source

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