Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Energy-Efficient and Survivable Optical Access Network Based on Multilayer-Ring Structure
An energy-efficient and survivable optical access network structure is proposed and investigated. Based on a structure model of multilayer-ring, the access network is divided into four layers and modules on a same layer are interconnected as a ring ...
Yunxin Lv +3 more
doaj +1 more source
Molecular bases of circadian magnesium rhythms across eukaryotes
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Multi-authority ABS supporting dendritic access structure
Attribute-based signature (ABS),which could realize fine-grained access control,was considered to be an important method for anonymous authentication in cloud computing.However,normal ABS only provided simple access control through threshold structure ...
Ruo MO, Jian-feng MA, Xi-meng LIU, Qi LI
doaj +2 more sources
PDBx/mmCIF Ecosystem: Foundation for FAIR Access to Macromolecular Structure Data [PDF]
Protein Data Bank (PDB, wwpdb.org, rcsb.org) is the single global repository for three-dimensional structures of biological macromolecules determined experimentally. PDB has been a pioneer in promoting open science and FAIR data practices worldwide. Open
Brinda Vallat
doaj +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Improved Real-Time Dynamic Migration Mechanism of Array Processor Data Cache
The on-chip distributed storage structure satisfies the high parallelism requirements of the array processor for memory access, and alleviates the problem of memory wall to some extent.
FENG Yani, JIANG Lin, SHAN Rui, LIU Yang, ZHANG Yuan
doaj +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Design for database access control mechanism based on blockchain
Aiming at the current problems of database access control,the thought of blockchain technology applied to database access control was proposed.The implementation mechanism of database access control based on blockchain was designed from several aspects ...
Yonggui FU, Jianming ZHU
doaj +2 more sources
Verifiable multi-secret sharing schemes applicable to arbitrary access structures
Verifiable multi-secret sharing on general access structures was studied.A method of construct verifiable se-cret sharing schemes with arbitrary access structure was given.The verifiable multi-secret sharing schemes constructed by this method have the ...
ZHANG Fu-tai1, WANG Yu-min2
doaj

