Results 51 to 60 of about 2,718,889 (304)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila
FEBS Letters, EarlyView.Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia +6 more
wiley +1 more source
Securing Access to Quality Mental Health Services in Primary Healthcare in Lebanon [PDF]
, 2014 The policy dialogue about Securing Access to Quality Mental Health Services in Primary Health Care in Lebanon was held on 24 April 2014 at the Gefinor Rotana Hotel, Beirut, Lebanon. The policy dialogue was facilitated by Dr.
El-Jardali, Fadi, Yehia, Farah
core
Integrating Palliative Care into the Health System in Lebanon [PDF]
, 2018 K2P Policy Briefs bring together global research evidence, local evidence and context-specific knowledge to inform deliberations about health policies and programmes.
Souiedan, Sara +2 more
core +2 more sources
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Open access to knowledge: a new right created by globalization
Revista Colombiana de Obstetricia y Ginecología, 2015 It emerges from the blurring of borders between countries, less independent control of the State over its citizens (1), and shorter effective time between an event occurring and news of it traveling around the world people (2).
Hernando Gaitán-Duarte
doaj +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
El acceso al saber requiere aplicar organización y representación del conocimiento
Revista Interamericana de Bibliotecología, 2010 Investigación documental que explica la importancia de los procesos de organización y representación del conocimiento (ORC) en el acceso expedito a las fuentes de información y conocimiento.
Tania Peña Vera
doaj
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Open Access and A2K: Collaborative Experiences in Latin America [PDF]
, 2012 In this chapter the access to knowledge (A2K) movement is based on definitions coined by theorists Benkler (2006), Balkin (2010) and Shaver (2007), who advance the concept of human development and equal access to knowl- edge as distributive justice. This
Gómez, Nancy Diana +3 more
core +1 more source