Results 61 to 70 of about 2,346,189 (262)
The Future Burden of Type 2 Diabetes in Belgium: A Microsimulation Model
ProceedingsBackground: Over 60 million people in Europe live with type 2 diabetes (T2D). This high burden is influenced by factors like population aging and increasingly prevalent risk factors such as excess weight, physical inactivity, unhealthy diets, and smoking.
José L. Peñalvo +5 more
doaj +1 more source
FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source
The right to public information in modern forms of its provision
Rozprawy SpołeczneAnalysis of the implementation of the right to public information in Poland in the context of modern forms of its disclosure. Material and methods Research of literature, Public Information Bulletins and responses to requests for access to public ...
Nikodem Kaczprzak
doaj +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
FREE ACCES TO PUBLIC INFORMATION IN LIGHT OF RECENT CJEU CASE LAW [PDF]
Challenges of the Knowledge SocietyAccess to public information is a constitutional right and is internationally recognized. The state guarantees applicants the right to free access to public information, establishing the conditions and procedures to be followed under the law, as well as ...
Elena Emilia ȘTEFAN
doaj
La (des)protección de la propiedad intelectual de las obras del poder público
Revista Vasca de Administración Pública, 2017 This work begins with an analysis about the vulnerability provoked by the intellectual property rules regarding works linked to the exercise of public power (either the legislative, the executive or the judiciary).
Juan Antonio Ureña Salcedo
doaj +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Knjižnica, 2001 Multiculturalism is one of the principles of library functioning. Each well-operated library tries to realise it by the contents of its collection and by providing access for all potential users.
Silva Novljan
doaj +1 more source