Results 81 to 90 of about 1,731,910 (308)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Zero Censorship! Who Are We Kidding?An exploratory analysis of the opinions and experiences of Queensland-based public librarians with regard to the censorship of materials in public library collections [PDF]

, 2004
Public librarians have long upheld the social justice philosophy of free access to information for all people. The issue of censorship is related to both the professional principles of the Australian Library and Information Association and to the role ...
Moody, Kim E., Moody, Kim
core  

Open Access for the Medical Librarian [PDF]

, 2006
The most important aspects of open access for the medical librarian are presented. Reasons for open access include access to research information, access to taxpayer-funded research, facilitation of evidence-based medicine, equity of access, promotion of
Waller, Andrew, Heather Morrison, Morrison, Heather, Andrew Waller   +3 more
core   +1 more source

Registros administrativos e inventarios en la normativa de suelos contaminados

Revista Vasca de Administración Pública, 2014
Public registries are considered suitable means to ease the diffusion of environmental information and therefore to benefit the access and participation of people in this field.
María del Carmen Bolaño Piñeiro
doaj   +1 more source

Access to public transport and labor informality [PDF]

IZA World of Labor, 2016
Public transport infrastructure has not kept up with the demands of growing populations in cities in developing countries. Infrastructure provision has historically been biased against less affluent areas, so access to formal jobs is often difficult and costly for a large part of the lower-income population.
openaire   +2 more sources

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

University libraries and public libraries: collaborate to provide access to information for all

, 2013
University libraries all over the world have managed to acquire access to large databases of scientific information. And many have set up repositories as ‘green road open access’ to assure free access to their own published academic output.
Heijne, Maria
core  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Measuring What Matters: Access to Destinations

, 2010
In what is likely to be an enduring period of constrained public resources, lawmakers and government executives will seek the best information possible for making policy choices and deciding where to make public investments.
Center for Transportation Studies
core