Results 71 to 80 of about 101,965,688 (300)
The Future Burden of Type 2 Diabetes in Belgium: A Microsimulation Model
ProceedingsBackground: Over 60 million people in Europe live with type 2 diabetes (T2D). This high burden is influenced by factors like population aging and increasingly prevalent risk factors such as excess weight, physical inactivity, unhealthy diets, and smoking.
José L. Peñalvo +5 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The right to public information in modern forms of its provision
Rozprawy SpołeczneAnalysis of the implementation of the right to public information in Poland in the context of modern forms of its disclosure. Material and methods Research of literature, Public Information Bulletins and responses to requests for access to public ...
Nikodem Kaczprzak
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
La (des)protección de la propiedad intelectual de las obras del poder público
Revista Vasca de Administración Pública, 2017 This work begins with an analysis about the vulnerability provoked by the intellectual property rules regarding works linked to the exercise of public power (either the legislative, the executive or the judiciary).
Juan Antonio Ureña Salcedo
doaj +1 more source
The Windsor Yearbook of Access to Justice, 2018 Among the strategies to improve public access to justice, increasing the accessibility and comprehensibility of legal information must be ranked as important. In this paper, the authors explore how libraries and librarians might play a role in providing
Beth Bilson +2 more
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
FREE ACCES TO PUBLIC INFORMATION IN LIGHT OF RECENT CJEU CASE LAW [PDF]
Challenges of the Knowledge SocietyAccess to public information is a constitutional right and is internationally recognized. The state guarantees applicants the right to free access to public information, establishing the conditions and procedures to be followed under the law, as well as ...
Elena Emilia ȘTEFAN
doaj
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source