Results 131 to 140 of about 6,349,237 (300)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Linked data for accessibility: from techniques to users

, 2013
The advanced characteristics of Linked Data drive the dramatic growth of accessible public data. With very few accessibility research projects applying Linked Data , this paper reviews the challenges of accessibility and proposes the approach to use ...
Ding, Chaohai, Wald, Mike, Wills, Gary
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Crowdsourcing-based web accessibility evaluation with golden maximum likelihood inference

, 2018
Web accessibility evaluation examines how well websites comply with accessibility guidelines which help people with disabilities to perceive, navigate and contribute to the Web.
Wang, Y, Bu, J, Song, S, Yu, Z, Artmeier, A, Wang, C, Shi, K   +6 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

National Accessibility Evaluation: Phase II [PDF]

This project implements activities for the National Accessibility Evaluation (NAE) pooled-fund study, performing accessibility evaluations describing conditions in 2020, 2021, 2022, 2023, and 2024.
Owen, Andrew, Liu, Shirley Shiqin, Lind, Eric M.   +2 more
core  

Quantitative metrics for measuring web accessibility

, 2007
This paper raises the need for quantitative accessibility measurement and proposes three different application scenarios where quantitative accessibility metrics are useful: Quality Assurance within Web Engineering, Information Retrieval and ...
M. VIGO, J. ABASCAL, R. LOMUSCIO, M. ARRUE, BRAJNIK, Giorgio, Giorgio Brajnik, Markel Vigo, Myriam Arrue, Julio Abascal, Raffaella Lomuscio   +9 more
core   +1 more source