Results 61 to 70 of about 209,676 (278)

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

Intrapancreatic accessory spleen in newborn with multiple congenital malformations

Current Issues in Pharmacy and Medical Sciences, 2012
A new case of intrapancreatic accessory spleen located in the tail of the pancreas in a premature male newborn is reported. The anomaly was unexpectedly found at the autopsy together with many other malformations including heart defects, polycystic ...
Justyna Szumiło, Dominika Stasiewicz, Agnieszka Fronczek, Wiktor Podlodowski, Franciszek Burdan   +4 more
doaj   +1 more source

Accessory spleen in pancreatic tail [PDF]

Journal of Surgical Case Reports, 2012
Intrapancreatic accessory spleens are common asymptomatic masses that generally cause no problems. Usually, they are incidentally found on imaging as a pancreatic mass and they pose a diagnostic and management dilemma due to equivocal imaging findings. Evolving imaging modalities and increasing use of endoscopic ultrasound with fine needle aspirate may
George, Mark, Evans, Tobias, Lambrianides, Andreas L.   +2 more
openaire   +2 more sources

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

The Morphological Variations of the Human Spleen [PDF]

Journal of Clinical and Diagnostic Research, 2012
Introduction: The spleen is an important lymphatic organ in the human body. Its immunological and haematological functions are being well realized now-a-days.
Prashant Nashiket Chaware, Swati Milind Belsare, Yashwant Ramkrishna Kulkarni, Sudhir Vishnupant Pandit, Jaideo Manohar Ughade   +4 more
doaj  

Contrast-enhanced sonography of intrapancreatic accessory spleen in six patients

, 2007
OBJECTIVE: The purpose of this article is to describe the characteristic findings of intrapancreatic accessory spleen over time on contrast-enhanced sonography.
Lee, Jeong Min, Han, Joon Koo, Lee, Jae Young, Kim, Se Hyung, Choi, Byung Ihn   +4 more
core   +1 more source

Retroperitoneal Accessory Spleen Presented As Metastatic Suprarenal Tumour- A Diagnostic Dilemma [PDF]

Journal of Clinical and Diagnostic Research, 2015
Accessory spleen may be formed during defective embryonic development. The retroperitoneal accessory spleen is a rare clinical entity and metastasis of renal carcinoma into this entity is extremely rare.
Rekha Porwal, Amit Singh, Pritesh Jain
doaj   +1 more source

An Intravesical Akkermansia muciniphila‐Based Chemo‐Immunotherapeutic Platform for Bladder Cancer

Advanced Science, EarlyView.
Pasteurized Akkermansia muciniphila is engineered into an intravesical F127/doxorubicin platform that couples localized chemotherapy with immune remodeling. By inducing apoptosis, ferroptosis, and immunogenic cell death, this chemo‐immunotherapeutic system enhances dendritic‐cell maturation, antigen cross‐presentation, and tumor‐specific CD8+ T‐cell ...
Rongkang Li, Anguo Zhao, Qi Zhuang, Lei Peng, Rui Liang, Jiadong Zhao, Yang Liu, Dashi Deng, Peng Yu, Xiqi Peng, Shaohua Zhang, Song Wu   +11 more
wiley   +1 more source

Overcoming Drug Resistance by Paclitaxel Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
In the murine triple‐negative breast cancer (TNBC) model, chemotherapy effectively increases tumor neoantigen burden (TNB). Here, the study constructs a liposomal nanovaccine using antigens derived from in vitro chemotherapy‐treated paclitaxel‐resistant TNBC 4T1 cells.
Bo Chen, Yangyi Wang, Tingting Li, Changqing Guo, Zhe Xie, Zhixian Zhang, Xinghua Han, Wei Wang, Jian Wang, Xiaopeng Ma, Yuanzeng Min   +10 more
wiley   +1 more source