Results 101 to 110 of about 314,600 (296)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Estimating household and community transmission of ocular Chlamydia trachomatis. [PDF]

, 2009
INTRODUCTION: Community-wide administration of antibiotics is one arm of a four-pronged strategy in the global initiative to eliminate blindness due to trachoma. The potential impact of more efficient, targeted treatment of infected households depends on
Anthony W Solomon, Muñoz Beatriz, Solomon, AW, Martin J Holland, Manoj Gambhir, Sheila West, Gambhir Manoj, Bailey Robin L., West, S, Basáñez María-Gloria, María-Gloria Basáñez, Bailey, RL, David C W Mabey, Basanez, M-G, Basáñez, María-Gloria, Grassly, NC, Nicholas C Grassly, Munoz, B, Mabey, DCW, Solomon, Anthony W, Gambhir, Manoj, Blake Isobel M., Blake, Isobel M, Solomon Anthony W., Burton, Matthew J, Burton Matthew J., Mabey David C. W., Grassly, Nicholas C, Beatriz Muñoz, Muñoz, Beatriz, Robin L Bailey, Holland, MJ, Bailey, Robin L, West, Sheila, Holland, Martin J, Blake, IM, Gambhir, M, West Sheila, Grassly Nicholas C., Isobel M Blake, Matthew J Burton, Holland Martin J., Mabey, David CW, Burton, MJ   +43 more
core   +2 more sources

Key working and the quality of relationships in secure accommodation [PDF]

, 2013
This article discusses the findings of a study which aimed to gain an insight into the views of young people in secure accommodation and their residential workers about the quality of relationships and, in particular, to explore the role of the key ...
Kendrick, Andrew, McKellar, Amy
core   +3 more sources

Descripción de morbilidad visual y ocular analizada en la Región Central de Colombia, acorde con los reportes RIPS (2013-2015)

Ciencia y Poder Aéreo, 2019
Visual and ocular pathologies are among the main causes of vision loss worldwide. Objective: to describe visual and ocular morbidity in the central region of Colombia according to reports from the database of Individual Records for Health Care Delivery ...
Jesús Daniel Gil, Jessica Alejandra Herrera Osorio, Olivia Margarita Narváez Rumie   +2 more
doaj   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Ocular rosacea

, 2005
Rosacea is a common skin disease that frequently involves the eye. Although the pathogenesis of the disease remains undefined, recent findings suggest that an altered inflammatory response plays an important role in both cutaneous and ocular rosacea ...
Mannis, Mark J. [UNIFESP], Alvarenga, Lênio Souza [UNIFESP]   +1 more
core   +1 more source

Influence of Blood Glycemia Levels in Refraction, Binocular Vision and Accommodation: A Case Report

Reports
This case report provides us with insight on how blood glycemia affects refraction, vergence and accommodation in a single diabetic patient. A 21-year-old type I diabetic woman was the subject studied in this report.
Marc Argilés, Jessica Sala-Oller, Bernat Sunyer-Grau, Cristina Rovira-Gay, Luis Pérez-Mañá   +4 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Non-strabismic Binocular Vision Anomalies among Eastern Nepalese Children: A Cross-sectional Study

Journal of Nepal Medical Association
Introduction: Non-strabismic binocular vision anomalies are the most prevalent undiagnosed/misdiagnosed visual disorders seen in clinical practice in the school-aged population. Methods: This was a planned cross-sectional research.
Priyanka Yadav, Anita Gupta, Purushottam Joshi   +2 more
doaj   +1 more source