Results 81 to 90 of about 314,600 (296)

The influence of tinted lenses upon ocular accommodation

Vision Research, 2001
We determined the effect upon accommodative responses of tinted lenses prescribed for the relief of visual discomfort in a group of five long term lens wearers. Static and dynamic responses were measured under four viewing conditions (1) prescribed tinted lens (2) neutral density filter (3) tinted lens of complementary colour and (4) no absorptive lens.
Simmers, Anita J., Gray, Lyle S., Wilkins, Arnold J.   +2 more
openaire   +2 more sources

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Surveillance for ocular hypertension : an evidence synthesis and economic evaluation [PDF]

, 2012
OBJECTIVES: To determine effective and efficient monitoring criteria for ocular hypertension [raised intraocular pressure (IOP)] through (i) identification and validation of glaucoma risk prediction models; and (ii) development of models to determine ...
Banister, K, Burr, JM, Kotecha, A, Garway-Heath, D., H Lemij, M Ryan, Tuulonen, A., Vale, L., Fraser, C., R Sanders, Crabb, D, Kotecha, A., Cook, J, Y Takwoingi, S Vernon, Takwoingi, Y., Banister, K., Fraser, C, Deeks, J, Sanders, R, A Tuulonen, Cook, J., Hernández, R, Glasziou, P, Tuulonen, A, Lemij, H., Vale, L, Burr, Jennifer Margaret, Elders, A., Burr, J.M., R Asaoka, Takwoingi, Y; id_orcid, Azuara-Blanco, A, P Glasziou, Botello-Pinzon, P, Garway-Heath, D, Ryan, Mandy, Vazquez-Montes, M, Lemij, H, Deeks, J., Takwoingi, Y, D Crabb, Azuara-Blanco, A.; id_orcid, L Vale, A Azuara-Blanco, Perera, R., Ryan, M, van der Schoot, J, Perera, R, Sanders, R., Crabb, D., Elders, A, D Garway-Heath, Ryan, M., R Hernández, K Banister, C Fraser, J Cook, J van der Schoot, Botello-Pinzon, P., A Elders, A Kotecha, Glasziou, P., Azuara-Blanco, A., King, A., J Deeks, JM Burr, A King, Burr, J M, Glasziou, Paul, King, A, Vernon, S, Asaoka, R., Vazquez-Montes, M., van der Schoot, J., Vernon, S., M Vazquez-Montes, Perera, Rafael, R Perera, Asaoka, R, Hernandez, R., P Botello-Pinzon, Azuara-Blanco, Augusto; id_orcid, King, Anthony J, Deeks, Jonathan J, Burr, Jennifer M, Azuara-Blanco, Augusto, Botello, Adriana P, Sanders, Roshini, Takwoingi, Yemisi, Garway-Heath, David F, Takwoingi, Yemisi; id_orcid, Lemij, Hans G   +92 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Supported Accommodation Services for Offenders:A Research Literature Review [PDF]

, 2008
This paper examines the links between homelessness and offending and provides a description of supported accommodation services provided by Sacro for offenders in Scotland and a summary of some of the main findings from research on the impact of supported
Richley, Tim, Kirkwood, Steve; id_orcid
core  

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

The ocular albinism type 1 protein, an intracellular G protein-coupled receptor, regulates melanosome transport in pigment cells [PDF]

, 2008
The protein product of the ocular albinism type 1 gene, named OA1, is a pigment cell-specific G protein-coupled receptor exclusively localized to intracellular organelles, namely lysosomes and melanosomes.
Bennett, DC, Venturi C, Palmigiano, A, Schiaffino, MV, Piccirillo, R, Altimare D., Rotondo G., Tacchetti, C, Marigo, V, Bagnato P., Coppola M., Rotondo, G, Venturi, C, Sviderskaya, EV, Palmisano I., Palmigiano A., Altimare D, Bagnato, P, Marigo V., Surace, EM, Altimare, D, Tacchetti C, Innamorati G., Venturi C., Surace E. M., Palmisano I, Rotondo G, INNAMORATI, Giulio, BALLABIO, ANDREA, Schiaffino M. V., Sviderskaya E. V., Palmigiano A, Innamorati G, SURACE, Enrico Maria, Sviderskaya EV, Piccirillo R, Bagnato P, Ballabio A., Incerti B, Piccirillo R., Tacchetti C., Schiaffino MV, Coppola, M, Incerti, B, Bennett DC, Incerti B., Palmisano, I, Coppola M, Bennett D. C., Innamorati, G, Ballabio, A, Marigo V   +51 more
core   +1 more source

Loss of amplitude of accommodation in pre-presbyopic HIV and AIDS patients under treatment with antiretrovirals

African Vision and Eye Health, 2017
Background: The prevalence of HIV and AIDS is causing an enormous public health burden. Its manifestations spare no organ. Ocular complications are mainly attributed to various opportunistic infections which are directly or indirectly caused by immune ...
Solani D. Mathebula, Prisilla S. Makunyane   +1 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source