Results 41 to 50 of about 12,436 (263)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Research progress in visual fatigue related to stereoscopic video display terminals
Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023 In recent years, with the development of science and technology, stereoscopic video display terminals have become more and more widely used in many fields.
LIU Lu, KE Bilian
doaj +1 more source
The quest for the human ocular accommodation mechanism
Acta Ophthalmologica, 2019 AbstractWe have known the accommodation phenomenon since 400 BC. Hypotheses about its mechanisms varied widely for two millennia. Early in the 17th century, when people became more aware of ophthalmic optics, Scheiner and Descartes were close to solving that accommodation worked by changes in the lens. Others rejected their idea, and people even denied
openaire +4 more sources
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
High-Order Aberrations: A Key Factor in Accommodative Dysfunctions
Applied SciencesThis study investigated the relationship between high-order aberrations (HOAs) and accommodative dysfunctions by analyzing their changes with accommodation.
Jessica Gomes, Sandra Franco
doaj +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Effects of Visual Display Unit on Ocular Accommodation in Young Adults
British and Irish Orthoptic JournalPurpose: To evaluate the impact of gaming on ocular accommodative parameters. Methods: A comparative and experimental study was conducted among non-orthoptic university students for a duration of six months from September 2023 to March 2024. After a half-
Vishal Biswas, Roshni Majumder
doaj +1 more source
Down syndrome: a review of ocular manifestations
Therapeutic Advances in Ophthalmology, 2022 Down syndrome is the most common genetically mediated intellectual disability. Although many physiologic and pathologic features of Down syndrome are discussed at length in the literature, the ocular manifestations of Down syndrome have seldom been ...
Abid Haseeb +7 more
doaj +1 more source
Eye movements in mild traumatic brain injury: Ocular biomarkers
Journal of Eye Movement Research, 2022 Mild traumatic brain injury (mTBI, or concussion), results from direct and indirect trauma to the head (i.e. a closed injury of transmitted forces), with or without loss of consciousness.
Matthew A. McDonald +2 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source