Results 91 to 100 of about 318,136 (312)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Tourism Products Characteristics and Forms [PDF]

The tourism product has to be packaged and priced keeping in mind the target customer. Without any doubt, tourism is the main sector that can play a significant part in achieving rapid economic growth and drastically reducing unemployment in our country.
Anca Gabriela Turtureanu
core   +1 more source

Location as a determinant of accommodation prices: managerial approach [PDF]

, 2014
In the presentation authors discuss the location-based factors’ impact on accommodation prices. The aim of the presentation is to compare the results of qualitative and quantitative research on location-based determinants of accommodation prices in Lodz ...
Leśniewska, Katarzyna, Napierała, Tomasz   +1 more
core  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Owner/managers perceptions on the influence of the accommodation sector on tourism and local well-being in Coffee Bay. [PDF]

African Journal of Hospitality, Tourism and Leisure, 2017
This research focuses on the role that the accommodation sector plays in the overall development of the tourism industry in the rural town of Coffee Bay, South Africa.
Siyabulela Nyikana, Ziyanda Sigxashe
doaj  

Green Choices: Exploring Environmental Responsible Practices and Their Impact on Guest Intention in Dinokeng Accommodation Establishments [PDF]

African Journal of Hospitality, Tourism and Leisure
As the hospitality industry is expanding in developing countries, it simultaneously contributes to environmental burdens. The purpose of this article is to determine the perceptions of guests towards environmentally responsible practices (ERPs), also ...
Lulama NDZUNGU, Antoinette ROELOFFZE, Carina KLEYNHANS   +2 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Efficiency differences in the tourist accommodation sector in Spain according to the type of establishment: a metafrontier analysis

Revista de Contabilidad: Spanish Accounting Review
The tourism industry is a major economic sector worldwide. This is especially so in Spain, which is a leading tourist destination. With globalisation, the sector has become highly competitive.
María Pilar Ibarrondo-Dávila, Jesús Vela-Victoria, Cristina María Campos-Alba, Gemma Pérez-López   +3 more
doaj   +1 more source