Results 11 to 20 of about 7,312 (174)

Association Between CYP2C19 Genotype and P2Y12 Reaction Units in Patients Receiving Clopidogrel After Acute Ischemic Stroke: A Prospective, Observational Study. [PDF]

Pharmacotherapy
ABSTRACT Background Recurrent stroke accounts for substantial morbidity and mortality worldwide, with up to 25% of ischemic strokes occurring in patients with prior strokes. Dual antiplatelet therapy (DAPT) with aspirin and clopidogrel is standard for secondary prevention after minor acute ischemic stroke (AIS) or high‐risk transient ischemic attack ...
Stone RM, Smith A, Gunter S, Weko AT, Gottschalk C, Lee C, Ramsey A, Weatherspoon MP, Worrall BB.   +8 more
europepmc   +2 more sources

Correction to "Translational Medicine in Alzheimer's Disease: The Journey of Donanemab From Discovery to Clinical Application". [PDF]

Chronic Dis Transl Med
Chronic Diseases and Translational Medicine, EarlyView.
europepmc   +2 more sources

Sulfated Cyclocarya Paliurus Polysaccharide Sorchestrates the Gut Microbiome to Mobilize a Host-Derived 12-HEPE Against Ulcerative Colitis. [PDF]

Adv Sci (Weinh)
A sulfated polysaccharide (SCP) from Cyclocarya paliurus alleviates ulcerative colitis by reshaping the gut microbiome. This remodeled microbiota orchestrates the upregulation of the host‐derived lipid 12‐HEPE, which directly inhibits the TLR4/NF‐κB pathway to suppress inflammation.
Chen X, Shen M, Zhang R, Huang Z, Niu H, Yu Q, Chen Y, Pan X, Rong L, Wen H, Yang J, Xie J.   +11 more
europepmc   +2 more sources

Are respiratory physicians adherent to guidelines when evaluating pulmonary nodules? [PDF]

Intern Med J
Abstract Introduction Although fewer than 1% of pulmonary nodules are malignant, appropriate evaluation is essential in optimising patient outcomes. The 2017 Fleischner Society Guidelines provide recommendations on management of incidentally detected nodules; however, studies to date have shown variable guideline adherence.
Tu L, Wong R, Baker A, O'Donoghue F, McDonald CF, Leong TL.   +5 more
europepmc   +2 more sources

Frequency and diagnostic significance of anti-cyclic citrullinated peptide antibodies (ACCP) and anti-modified citrullinated vimentin antibodies (AMCV) in children with early juvenile arthritis

Научно-практическая ревматология, 2008
Objective. To determine frequency of anti-cyclic citrullinated peptide antibodies (ACCP) and anti-modified citrullinated vimentin antibodies (AMCV) elevation and their diagnostic significance in children with early juvenile arthritis (JA).
S O Salugina, E S Fedorov, E N Alexandrova, A A Novikov, A A Baranov, Y A Valogina, M. V. Cherkasova, T N Nikolaeva, N A Subova   +8 more
doaj   +1 more source

Transcriptional signature associated with early rheumatoid arthritis and healthy individuals at high risk to develop the disease. [PDF]

PLoS ONE, 2018
Little is known regarding the mechanisms underlying the loss of tolerance in the early and preclinical stages of autoimmune diseases. The aim of this work was to identify the transcriptional profile and signaling pathways associated to non-treated early ...
N Macías-Segura, J E Castañeda-Delgado, Y Bastian, D Santiago-Algarra, J D Castillo-Ortiz, A L Alemán-Navarro, E Jaime-Sánchez, M Gomez-Moreno, C A Saucedo-Toral, Edgar E Lara-Ramírez, M Zapata-Zuñiga, L Enciso-Moreno, R González-Amaro, C Ramos-Remus, J A Enciso-Moreno   +14 more
doaj   +1 more source

Relationship of immunogenetic and immunologic markers and their influence on disease activity and radiological progression in patients with early rheumatoid arthritis

Научно-практическая ревматология, 2009
Relationship of immunogenetic and immunologic markers and their influence on disease activity and radiological progression in patients with early rheumatoid arthritis. Objective.
N V Demidova
doaj   +1 more source

Impact of thromboprophylaxis across the US acute care setting. [PDF]

PLoS ONE, 2015
The risk of venous thromboembolism (VTE) can be reduced by appropriate use of anticoagulant prophylaxis. VTE prophylaxis does, however, remain substantially underused, particularly among acutely ill medical inpatients.
Wei Huang, Frederick A Anderson, Sophie K Rushton-Smith, Alexander T Cohen   +3 more
doaj   +1 more source

The Association of Interleukin-17 and ACCP levels with Rheumatoid arthritis patients and Control Groups

مجلة الكوفة الطبية, 2023
Background: Rheumatoid arthritis (RA) represents the prevailing form of chronic inflammatory polyarthritis, characterized by an autoimmune response directed against citrullinated antigens and subsequent synovial joint destruction.
Haneen Jassim, Thanaa Al-Turaihi
doaj   +1 more source

Biological therapy of seropositive juvenile idiopathic arthritis: Results of a retrospective single-center study

Научно-практическая ревматология, 2023
Seropositive juvenile idiopathic arthritis (JIA) is one of the rarest and most unfavorable subtypes of juvenile arthritis, characterized by an increased frequency of inefficacy of therapy.
M. I. Kaleda, Z. A. Kolkhidova, I. P. Nikishina   +2 more
doaj   +1 more source