Results 151 to 160 of about 306,823 (323)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Generalized Pseudo‐Newtonian Potential for Studying Accretion Disk Dynamics in Off‐Equatorial Planes around Rotating Black Holes: Description of a Vector Potential [PDF]
, 2007 Shubhrangshu Ghosh +1 more
openalex +1 more source
TREX1, a predator for treating MSI‐H tumors?
Molecular Oncology, EarlyView.Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
X-Ray Views of Galactic Accreting Pulsars in High-Mass X-Ray Binaries
UniverseAccreting X-ray pulsars, located in X-ray binaries, are neutron stars with magnetic fields as strong as B∼1012–13 G. This review offers a concise overview of the accretion and radiation processes of X-ray pulsars and summarizes their rich observational ...
Shan-Shan Weng, Long Ji
doaj +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Journal of Tropical Soils, 2011 Surround a big river estuary coastline has a dynamic characteristic and change along a period of time, because of a natural process and/or it is accelerated by human activities.
Fahri, Tamaluddin Syam
doaj
Tracking Supermassive Black Hole Mergers from kpc to sub-pc Scales with AXIS
UniverseWe present an analysis showcasing how the Advanced X-ray Imaging Satellite (AXIS), a proposed NASA Probe-class mission, will significantly increase our understanding of supermassive black holes undergoing mergers—from kpc to sub-pc scales. In particular,
Adi Foord +10 more
doaj +1 more source
Thermal and Viscous Instability of Accretion Disc in AGN [PDF]
, 2000 Agnieszka Janiuk, B. Czerny
openalex +1 more source