Results 151 to 160 of about 305,897 (326)

X-Ray Views of Galactic Accreting Pulsars in High-Mass X-Ray Binaries

open access: yesUniverse
Accreting X-ray pulsars, located in X-ray binaries, are neutron stars with magnetic fields as strong as B∼1012–13 G. This review offers a concise overview of the accretion and radiation processes of X-ray pulsars and summarizes their rich observational ...
Shan-Shan Weng, Long Ji
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Coastline Change Surround Sekampung River Estuary Estimated by Geographic Information System Technique

open access: yesJournal of Tropical Soils, 2011
Surround a big river estuary coastline has a dynamic characteristic and change along a period of time, because of a natural process and/or it is accelerated by human activities.
Fahri, Tamaluddin Syam
doaj  

Tracking Supermassive Black Hole Mergers from kpc to sub-pc Scales with AXIS

open access: yesUniverse
We present an analysis showcasing how the Advanced X-ray Imaging Satellite (AXIS), a proposed NASA Probe-class mission, will significantly increase our understanding of supermassive black holes undergoing mergers—from kpc to sub-pc scales. In particular,
Adi Foord   +10 more
doaj   +1 more source

Observational limits on type 1 active galactic nucleus rate in COSMOS [PDF]

open access: yes, 2009
We present black hole masses and accretion rates for 182 Type 1 active galactic nuclei (AGNs) in COSMOS. We estimate masses using the scaling relations for the broad H β, Mg ii, and C iv emission lines in the redshift ranges 0.16 < z < 0.88, 1 < z < 2 ...
Bongiorno, Angela   +15 more
core  

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui   +6 more
wiley   +1 more source

An analytic relation for the thickness of accretion flows [PDF]

open access: green, 2010
Zhen-Yi Cai   +3 more
openalex   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

open access: yesMolecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken   +3 more
wiley   +1 more source

Simulations of flux variability of oscillating accretion fluid tori around Kerr black holes [PDF]

open access: bronze, 2014
Pavel Bakala   +6 more
openalex   +1 more source

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