Results 131 to 140 of about 118,894 (281)

The IMF of stellar clusters: effects of accretion and feedback

, 2010
We have developed a model which describes the co-evolution of the mass function of dense gravitationally bound cores and of the stellar mass function in a protocluster clump.
Dib, Sami, Padoan, Paolo, Maheswar, G., Ojha, D. K., Khajenabi, Fazeleh, Shadmehri, Mohsen   +5 more
core   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

Supermassive Black Hole Winds in X-rays: SUBWAYS

Astronomy & Astrophysics
We present the X-ray analysis of coronal properties in a statistically representative sample of 23 mostly radio-quiet active galactic nuclei (AGN) from the SUpermassive Black holes Winds in X-rAYs campaign (SUBWAYS), focusing on quasars at redshifts 0.1 
Peluso S., Lanzuisi G., Comastri A., Brusa M., Giustini M., Miniutti G., Bianchi S., Gianolli V. E., Middei R., Petrucci P-O., Borrelli L., Amenta E., Bertola E., Vignali C., De Marco B., De Rosa A., Kraemer S., Kriss G., Krongold Y., Longinotti A. L., Mathur S., Merloni A., Nardini E., Panessa F., Piconcelli E., Ponti G., Ricci F., Tortosa A., Zappacosta L., Serafinelli R., Matzeu G. A.   +30 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Timing and spectral analysis of the 2025 outburst of 4U 1630−47 with NICER

Astronomy & Astrophysics
We analyzed NICER observations of the 2025 outburst of the black hole X-ray binary 4U 1630−47 to investigate the spectral–timing properties of its transient low-frequency quasi-periodic oscillations (QPOs) and millihertz-scale quasi-regular modulation ...
Zhu Haifan, Méndez Mariano, Chen Xiao, Wang Wei   +3 more
doaj   +1 more source

Constraints on radiatively inefficient accretion history from Eddington ratio distribution of active galactic nuclei

, 2007
The transition of a standard thin disc to a radiatively inefficient accretion flow (RIAF) is expected to occur when m similar to m(crit)(m =. M/M-Edd).
Xu, Ya-Di, Cao, Xinwu
core   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source