Results 131 to 140 of about 278,789 (290)

Improving accretion diagnostics for young stellar objects with mid-infrared hydrogen lines from JWST/MIRI

Astronomy & Astrophysics
Context. We present a comprehensive study of mid-infrared neutral hydrogen (H i) emission lines in 79 nearby (d < 200 pc) young stars using the James Webb Space Telescope (JWST) Mid-Infrared Instrument (MIRI).
Shridharan B., Manoj P., Pathak Vinod Chandra, Caratti o Garatti A., Banerjee Bihan, Henning Th., Kamp I., van Dishoeck E., Tyagi H., Arun R., Mathew B., Güdel M., Lagage P.-O.   +12 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Super-Eddington accretion in protogalactic cores

Astronomy & Astrophysics
The presence of massive black holes (BHs) exceeding 109 M⊙ already at redshift z > 6 challenges standard models of BH growth. Super-Eddington (SE) accretion has emerged as a promising mechanism to solve this issue, yet its impact on early BH evolution in
Zana Tommaso, Capelo Pedro R., Boresta Mairo, Schneider Raffaella, Lupi Alessandro, Trinca Alessandro, Mayer Lucio, Valiante Rosa, Graziani Luca   +8 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Chemical evolution and kilonova implications of post-merger accretion disk winds

Astronomy & Astrophysics
Context. Several gamma-ray bursts (GRBs) have recently been associated with kilonova emission. We study the mechanisms that account for this effect by means of the radioactive decay of elements synthesized in accretion disk winds. Aims.
Janiuk Agnieszka, Saji Joseph, Urrutia Gerardo   +2 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Optical Variability of Active Galactic Nuclei

Frontiers in Astronomy and Space Sciences, 2017
Szymon Kozłowski
doaj   +1 more source

The role of radiation pressure in accreting massive black hole binaries

Astronomy & Astrophysics
We investigate the impact of radiation pressure on the circumbinary discs surrounding accreting massive black hole binaries (MBHBs) at milli-parsec separations using 3D hyper-Lagrangian resolution hydrodynamic simulations.
Cocchiararo Fabiola, Franchini Alessia, Lupi Alessandro, Sesana Alberto   +3 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Space-time in motion: An evolving relativistic binary black hole metric for GIZMO

Astronomy & Astrophysics
The last evolutionary stages of massive black hole binaries prior to coalescence are dominated by the emission of gravitational waves, which will be probed by the future Laser Interferometer Space Antenna.
Fedrigo Giacomo, Lupi Alessandro, Franchini Alessia, Bonetti Matteo   +3 more
doaj   +1 more source