Results 121 to 130 of about 118,894 (281)
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Optical Variability of Active Galactic Nuclei
Frontiers in Astronomy and Space Sciences, 2017 Szymon Kozłowski
doaj +1 more source
Space-time in motion: An evolving relativistic binary black hole metric for GIZMO
Astronomy & AstrophysicsThe last evolutionary stages of massive black hole binaries prior to coalescence are dominated by the emission of gravitational waves, which will be probed by the future Laser Interferometer Space Antenna.
Fedrigo Giacomo +3 more
doaj +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Super-Eddington accretion in protogalactic cores
Astronomy & AstrophysicsThe presence of massive black holes (BHs) exceeding 109 M⊙ already at redshift z > 6 challenges standard models of BH growth. Super-Eddington (SE) accretion has emerged as a promising mechanism to solve this issue, yet its impact on early BH evolution in
Zana Tommaso +8 more
doaj +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Astronomy & AstrophysicsContext. We present a comprehensive study of mid-infrared neutral hydrogen (H i) emission lines in 79 nearby (d < 200 pc) young stars using the James Webb Space Telescope (JWST) Mid-Infrared Instrument (MIRI).
Shridharan B. +12 more
doaj +1 more source
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
The role of radiation pressure in accreting massive black hole binaries
Astronomy & AstrophysicsWe investigate the impact of radiation pressure on the circumbinary discs surrounding accreting massive black hole binaries (MBHBs) at milli-parsec separations using 3D hyper-Lagrangian resolution hydrodynamic simulations.
Cocchiararo Fabiola +3 more
doaj +1 more source