Results 111 to 120 of about 118,894 (281)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Signature of iron line profile from a Kerr-like wormhole

Astronomy & Astrophysics
Context. Broad and skewed iron Kα emission lines in the X-ray spectra of accreting black holes encode key information about space-time geometry in the innermost disk regions.
Liu Cheng, Siew Hoongwah, Jiang Hong-Xuan, Mizuno Yosuke, Zhu Tao   +4 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

You can’t see me: Super-Eddington growth hindering X-ray detection in high-z broad-line active galactic nuclei

Astronomy & Astrophysics
We revisit black hole mass estimates for high-redshift broad-line active galactic nuclei (AGNs) discovered with JWST by jointly analysing their broad emission lines and their systematic non-detections in deep Chandra imaging.
Trinca Alessandro, Lupi Alessandro, Haardt Francesco, Madau Piero   +3 more
doaj   +1 more source

Hot one-temperature accretion flows revisited [PDF]

, 2006
The effectiveness of the thermal coupling of ions and electrons in optically thin, hot accretion flows is investigated in a phenomenological approach. In the limit of complete coupling, we focus on the one-temperature accretion flows around black holes ...
Taam, R. E., Yuan, F, Cui, W., Xue, Y. Q., Taam, RE, Cui, W, Xue, YQ, Yuan, F.   +7 more
core  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

A deep X-ray and UV look into the reflaring stage of the accreting millisecond pulsar SAX J1808.4−3658

Astronomy & Astrophysics
We present a detailed X-ray and UV high-time-resolution monitoring of the final reflaring phase of the 2022 outburst of the accreting millisecond pulsar SAX J1808.4−3658, based on simultaneous XMM-Newton and Hubble Space Telescope (HST) observations. The
Ballocco C., Papitto A., Miraval Zanon A., Illiano G., Di Salvo T., Ambrosino F., Burderi L., Campana S., Coti Zelati F., Di Marco A., Malacaria C., Pilia M., Poutanen J., Salmi T., Sanna A.   +14 more
doaj   +1 more source

The Properties of AGN in the context of X-ray Binaries [PDF]

, 2009
Black holes are undoubtedly the most fascinating and exciting objects in the Universe, capturing the imagination of scientists and film writers alike. It has been a long standing objective of the scientific community to understand how these objects work ...
Middleton, Matthew James, MIDDLETON, MATTHEW,JAMES   +1 more
core  

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Spiral formation caused by late infall onto protoplanetary disks

Astronomy & Astrophysics
The classical picture that planet formation occurs in protoplanetary disks that are isolated from their environment is undergoing a major shift toward a more connected picture.
Hühn L.-A., Kimmig C. N., Dullemond C. P.   +2 more
doaj   +1 more source