Results 91 to 100 of about 26,045 (258)

Evolution of the Shoreline Between the Ports of Valencia and Sagunto, Spain (1957–2024)

Journal of Marine Science and Engineering
Coastal areas are increasingly affected by erosion due to climate change and human interventions, threatening the stability of many shorelines. Understanding coastal dynamics is therefore crucial for developing effective conservation and management ...
Joan Ortiz Vivas, Ana María Blázquez Morilla, Borja Martínez-Clavel Valles   +2 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Cyclic light variations and accretion disk evolution in the Large Magellanic Cloud eclipsing binary OGLE-LMC-DPV-062

Astronomy & Astrophysics
Context. Many intermediate-mass close binaries exhibit photometric cycles longer than their orbital periods, likely linked to variations in their accretion disks.
Mennickent R. E., Djurašević G., Rosales J. A., Garcés J., Petrović J., Schleicher D. R. G., Soszyński I.   +6 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

The elusive cyclotron line in 4U 1901+03: Hidden, yet present

Astronomy & Astrophysics
Context. Cyclotron resonant scattering features in accreting X-ray pulsars are often difficult to detect, especially when shallow or variable. Recent studies have shown that combining spectral and timing analyses enhances their detectability. Aims.
Ambrosi Elena, D’Aí Antonino, Cusumano Giancarlo, Ferrigno Carlo, Sokolova-Lapa Ekaterina, Maniadakis Dimitrios K., Tutone Antonio, Vasilopoulos Georgios, Kretschmar Peter, Malacaria Christian, Pintore Fabio   +10 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

A deep X-ray and UV look into the reflaring stage of the accreting millisecond pulsar SAX J1808.4−3658

Astronomy & Astrophysics
We present a detailed X-ray and UV high-time-resolution monitoring of the final reflaring phase of the 2022 outburst of the accreting millisecond pulsar SAX J1808.4−3658, based on simultaneous XMM-Newton and Hubble Space Telescope (HST) observations. The
Ballocco C., Papitto A., Miraval Zanon A., Illiano G., Di Salvo T., Ambrosino F., Burderi L., Campana S., Coti Zelati F., Di Marco A., Malacaria C., Pilia M., Poutanen J., Salmi T., Sanna A.   +14 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Optical Variability of Active Galactic Nuclei

Frontiers in Astronomy and Space Sciences, 2017
Szymon Kozłowski
doaj   +1 more source

Spiral formation caused by late infall onto protoplanetary disks

Astronomy & Astrophysics
The classical picture that planet formation occurs in protoplanetary disks that are isolated from their environment is undergoing a major shift toward a more connected picture.
Hühn L.-A., Kimmig C. N., Dullemond C. P.   +2 more
doaj   +1 more source