Results 81 to 90 of about 278,789 (290)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Magnetohydrodynamical modeling of star-disk formation: from isolated spherical collapse towards incorporation of external dynamics

Frontiers in Astronomy and Space Sciences
The formation of protostars and their disks has been understood as the result of the gravitational collapse phase of an accumulation of dense gas that determines the mass reservoir of the star-disk system.
Michael Kuffmeier
doaj   +1 more source

Dust growth in the interstellar medium: How do accretion and coagulation interplay?

, 2012
Dust grains grow in interstellar clouds by accretion and coagulation. In this paper, we focus on these two grain growth processes and numerically investigate how they interplay to increase the grain radii.
Asano, Bohren, Brauer, Cardelli, Cazaux, Chokshi, Cox, Dominik, Draine, Draine, Dwek, Désert, Evans, Fukui, Gall, Gallerani, Grassi, Hellyer, Hirashita, Hirashita, Hirashita, Hirashita, Hirashita, Hiroyuki Hirashita, Inoue, Inoue, Jang, Jones, Jones, Jones, Koda, Kozasa, Lada, Leisawitz, Leitch-Devlin, Mathis, Mathis, McKee, Michałowski, Nozawa, Ormel, Ormel, Ossenkopf, O’Donnell, Pei, Pipino, Savage, Spitzer, Stepnik, Valiante, Valiante, Weidenschilling, Weingartner, Weingartner, Wilson, Yamasawa, Yan, Zhukovska   +57 more
core   +1 more source

Subsonic wind accretion

Monthly Notices of the Royal Astronomical Society, 2022
ABSTRACT The rate of subsonic wind accretion (accretion on a point Newtonian mass moving through uniform gas) is shown to be independent of the wind velocity and equal to the spherical Bondi rate – for the adiabatic index equal to 5/3.
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Gas Accretion in Star-Forming Galaxies

, 2016
Cold-mode gas accretion onto galaxies is a direct prediction of LCDM simulations and provides galaxies with fuel that allows them to continue to form stars over the lifetime of the Universe.
A. B. Ford, A. Boksenberg, A. Dekel, A. Dekel, A. J. Battisti, A. M. Brooks, A. M. Diamond-Stanic, A. M. Wolfe, B. A. Keeney, B. D. Oppenheimer, B. D. Savage, B. E. Penprase, B. P. Wakker, C. C. Steidel, C. C. Steidel, C. C. Steidel, C. J. Liang, C. L. Martin, C. Péroux, C. Thom, C. W. Churchill, C. W. Churchill, C. W. Churchill, C. W. Danforth, C.-A. Faucher-Giguère, D. C. Martin, D. C. Martin, D. Kereš, D. Kereš, D. Kunth, D. V. Bowen, F. Voort van de, F. Voort van de, G. C. Rudie, G. G. Kacprzak, G. G. Kacprzak, G. G. Kacprzak, G. G. Kacprzak, G. G. Kacprzak, G. G. Kacprzak, G. G. Kacprzak, G. G. Kacprzak, G. G. Kacprzak, H. Rahmani, H.-W. Chen, H.-W. Chen, H.-W. Chen, H.-W. Chen, H.-W. Chen, H.-W. Chen, I. Schroetter, J. Bergeron, J. C. Charlton, J. C. Charlton, J. D. Meiring, J. F. Navarro, J. N. Bregman, J. N. Burchett, J. N. Burchett, J. Ribaudo, J. T. Stocke, J. T. Stocke, J. Tumlinson, J. X. Prochaska, J. X. Prochaska, J. X. Prochaska, J.-K. Krogager, K. H. R. Rubin, K. L. Adelberger, K. L. Cooksey, K. M. Lanzetta, K. R. Sembach, K. R. Stewart, K. R. Stewart, M. Danovich, M. Danovich, M. Fumagalli, M. Fumagalli, M. Fumagalli, M. Fumagalli, M. Rafelski, N. Bouché, N. Bouché, N. Bouché, N. H. M. Crighton, N. H. M. Crighton, N. H. M. Crighton, N. L. Mathes, N. Lehner, N. Lehner, N. M. Nielsen, N. M. Nielsen, N. M. Nielsen, N. M. Nielsen, N. Yoshida, P. Guillemin, P. Ocvirk, P. Richter, P. Richter, R. A. Jorgenson, R. A. Jorgenson, R. Bordoloi, R. Bordoloi, R. Bordoloi, R. Cooke, R. J. Cooke, S. Borthakur, S. Côté, S. D. Johnson, S. D. Johnson, S. L. Ellison, S. Muzahid, S. Muzahid, S. Quiret, S. Shen, S. Shen, S. Zibetti, T. Goerdt, T. J. Cooper, T. Kimm, T. M. Tripp, T. M. Tripp, T. M. Tripp, T.-W. Lan, Y. Birnboim, Y. Zheng   +125 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Phantom Accretion onto the Schwarzschild de-Sitter Black Hole

, 2011
We deal with phantom energy accretion onto the Schwarzschild de-Sitter black hole. The energy flux conservation, relativistic Bernoulli equation and mass flux conservation equation are formulated to discuss the phantom accretion.
Babichev E, Bennett C L, Bondi H, Caldwell R R, G Abbas, Hinshaw G, M Sharif, Nagai H, Padmanabhan T, Perlmutter S, Perlmutter S, Riess A G, Sahni V, Sen A J, Spergel D N, Sung-Won K   +15 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source