Results 61 to 70 of about 118,894 (281)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Granitoids of the Ufaley Block: Geodynamic environments, age, sources, problems
Литосфера, 2016 There are complex of data about composition, age, isotopic parameters for granites from the Ufaley block, which is situated in the accretion zone on the boundary between the Urals and the East European platform.
G. Yu. Shardakova
doaj
Dynamics and accretion of planetesimals [PDF]
Progress of Theoretical and Experimental Physics, 2012 We review the basic dynamics and accretion of planetesimals by showing N-body simulations. The orbits of planetesimals evolve through two-body gravitational relaxation: viscous stirring increases the random velocity and dynamical friction realizes the equiparation of the random energy.
Kokubo, Eiichiro, Ida, Shigeru
openaire +2 more sources
A magnetic accretion switch in pre-cataclysmic binaries [PDF]
, 2014 We have investigated the mass accretion rate implied by published surface abundances of Si and C in the white dwarf component of the 3.62 h period pre-cataclysmic binary and planet host candidate QS Vir (DA+M2−4).
Drake, Jeremy J. +3 more
core +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Study of Ice Accretion on Horizontal Axis Wind Turbine Blade using 2D and 3D Numerical Approach [PDF]
, 2020 In order to optimize the wind turbine operation in ice prone cold regions, it is important to better understand the ice accretion process and how it affects the wind turbine performance.
Hu, Qin +4 more
core +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Accretion-induced variability links young stellar objects, white dwarfs, and black holes
, 2015 The central engines of disc-accreting stellar-mass black holes appear to be scaled down versions of the supermassive black holes that power active galactic nuclei.
C. Knigge (7590077) +8 more
core +4 more sources
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source