Results 51 to 60 of about 118,894 (281)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Accretion disc particle accretion in major merger simulations [PDF]
Monthly Notices of the Royal Astronomical Society, 2013 A recent approach to simulating localized feedback from active galactic nuclei by Power et al. (2011) uses an accretion disc particle to represent both the black hole and its accretion disc. We have extrapolated and adapted this approach to simulations of Milky Way-sized galaxy mergers containing black holes and explored the impact of the various ...
Wurster, James Howard +1 more
openaire +3 more sources
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
UniverseAccretion and migration usually proceed concurrently for giant planet formation in the natal protoplanetary disks. Recent works indicate that the concurrent accretion onto a giant planet imposes significant impact on the planetary migration dynamics in ...
Hening Wu, Ya-Ping Li
doaj +1 more source
Magnetically gated accretion in an accreting ‘non-magnetic’ white dwarf [PDF]
Nature, 2017 White dwarfs are often found in binary systems with orbital periods ranging from tens of minutes to hours in which they can accrete gas from their companion stars. In about 15% of these binaries, the magnetic field of the white dwarf is strong enough ($\geq 10^6$ Gauss) to channel the accreted matter along field lines onto the magnetic poles.
Scaringi S +4 more
openaire +9 more sources
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
, 1995 49p. To appear in XXI Canary Islands Winter School of Astrophysics, ed. T. Shahbaz, CUP (significantly improved, expanded and updated version of an earlier text)
openaire +6 more sources
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Frontiers in Astronomy and Space SciencesThe formation of protostars and their disks has been understood as the result of the gravitational collapse phase of an accumulation of dense gas that determines the mass reservoir of the star-disk system.
Michael Kuffmeier
doaj +1 more source