Results 71 to 80 of about 26,045 (258)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

X-ray and radio observations of the AMXP MAXI J1957+032 covering the 2022–2025 outbursts

Astronomy & Astrophysics
We presented a comprehensive multi-epoch timing and multiwavelength analysis of the accreting millisecond X-ray pulsar MAXI J1957+032, covering two major outbursts in 2022 and 2025.
Li Zhaosheng, Kuiper Lucien, Pan Yuanyue, Xu Renxin, Ge Mingyu, Weng Shanshan, Peng Long, Yu Wenhui, Huang Yue, Zhang Liang, Song Liming, Molkov Sergey V., Lutovinov Alexander A., Zhang Shu, Zhang Shuang-Nan   +14 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Interaction between disk and extended corona in a general relativistic framework

Astronomy & Astrophysics
Context. The energy equilibrium between the corona and the underlying disk in a two-phase accretion flow sets a lower limit on the achievable photon index.
Datta Sudeb Ranjan, Bursa Michal, Dovciak Michal, Zhang Wenda   +3 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

XMM-Newton multi-year campaign on NGC 55 ULX-1

Astronomy & Astrophysics
Context. Winds are an important ingredient in the evolution of X-ray binary (XRB) systems, particularly those at high accretion rates such as ultra-luminous X-ray sources (ULXs), because they may regulate the accretion of matter onto the compact object ...
Pinto C., Caserta S., Barra F., Xu Y., Barret D., Kosec P., La Palombara N., Marino A., Pintore F., Riggio A., Roberts T. P., Salvaggio C., Sidoli L., Soria R., Walton D. J.   +14 more
doaj   +1 more source

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

Double-hump spectrum, pulse profile dip, and pulsed fraction spectra from the low-accretion regime in the X-ray pulsar MAXI J0655-013

Astronomy & Astrophysics
Context. Accreting X-ray pulsars (XRPs) undergo different physical regimes depending on different mass accretion rates, with related changes in the emitted X-ray spectral properties.
Malacaria C., Pike S. N., D’Aì A., Israel G. L., Ducci L., Rothschild R. E., Stella L., Amato R., Ambrosi E., Coley J. B., Fürst F., Imbrogno M., Kretschmar P., Maniadakis D. K., Papitto A., Pradhan P., Rouco Escorial A., Simongini A., Stierhof J., West B. F., Zalot N.   +20 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Paradox of the Moving Boundary: Legal Heredity of River Accretion and Avulsion

Water Alternatives, 2011
International boundaries – the divisions between state jurisdictions – are characterised in law by their inherent rigidity. Yet recent research has revealed that well over one-third of the total length of international boundaries follow rivers or streams
John W. Donaldson
doaj