Results 101 to 110 of about 26,045 (258)
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Space-time in motion: An evolving relativistic binary black hole metric for GIZMO
Astronomy & AstrophysicsThe last evolutionary stages of massive black hole binaries prior to coalescence are dominated by the emission of gravitational waves, which will be probed by the future Laser Interferometer Space Antenna.
Fedrigo Giacomo +3 more
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Super-Eddington accretion in protogalactic cores
Astronomy & AstrophysicsThe presence of massive black holes (BHs) exceeding 109 M⊙ already at redshift z > 6 challenges standard models of BH growth. Super-Eddington (SE) accretion has emerged as a promising mechanism to solve this issue, yet its impact on early BH evolution in
Zana Tommaso +8 more
doaj +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Astronomy & AstrophysicsContext. We present a comprehensive study of mid-infrared neutral hydrogen (H i) emission lines in 79 nearby (d < 200 pc) young stars using the James Webb Space Telescope (JWST) Mid-Infrared Instrument (MIRI).
Shridharan B. +12 more
doaj +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
The role of radiation pressure in accreting massive black hole binaries
Astronomy & AstrophysicsWe investigate the impact of radiation pressure on the circumbinary discs surrounding accreting massive black hole binaries (MBHBs) at milli-parsec separations using 3D hyper-Lagrangian resolution hydrodynamic simulations.
Cocchiararo Fabiola +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source