Results 101 to 110 of about 26,473 (258)
FEBS Letters, EarlyView.Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley +1 more source
Space-time in motion: An evolving relativistic binary black hole metric for GIZMO
Astronomy & AstrophysicsThe last evolutionary stages of massive black hole binaries prior to coalescence are dominated by the emission of gravitational waves, which will be probed by the future Laser Interferometer Space Antenna.
Fedrigo Giacomo +3 more
doaj +1 more source
Identification of the plant mitochondrial OrfX protein: A mass spectrometry approach
FEBS Letters, EarlyView.The mitochondrial genome of plants contains an open reading frame, orfx, which encodes a rare protein that has so far escaped mass spectrometric detection. The protein resembles the c‐subunit of bacterial twin‐arginine‐motif‐dependent protein translocases (TatC).
Matthias Döring +3 more
wiley +1 more source
Super-Eddington accretion in protogalactic cores
Astronomy & AstrophysicsThe presence of massive black holes (BHs) exceeding 109 M⊙ already at redshift z > 6 challenges standard models of BH growth. Super-Eddington (SE) accretion has emerged as a promising mechanism to solve this issue, yet its impact on early BH evolution in
Zana Tommaso +8 more
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Astronomy & AstrophysicsContext. We present a comprehensive study of mid-infrared neutral hydrogen (H i) emission lines in 79 nearby (d < 200 pc) young stars using the James Webb Space Telescope (JWST) Mid-Infrared Instrument (MIRI).
Shridharan B. +12 more
doaj +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
The role of radiation pressure in accreting massive black hole binaries
Astronomy & AstrophysicsWe investigate the impact of radiation pressure on the circumbinary discs surrounding accreting massive black hole binaries (MBHBs) at milli-parsec separations using 3D hyper-Lagrangian resolution hydrodynamic simulations.
Cocchiararo Fabiola +3 more
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source