Results 101 to 110 of about 278,789 (290)

Evolution of the Shoreline Between the Ports of Valencia and Sagunto, Spain (1957–2024)

Journal of Marine Science and Engineering
Coastal areas are increasingly affected by erosion due to climate change and human interventions, threatening the stability of many shorelines. Understanding coastal dynamics is therefore crucial for developing effective conservation and management ...
Joan Ortiz Vivas, Ana María Blázquez Morilla, Borja Martínez-Clavel Valles   +2 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

X-ray and radio observations of the AMXP MAXI J1957+032 covering the 2022–2025 outbursts

Astronomy & Astrophysics
We presented a comprehensive multi-epoch timing and multiwavelength analysis of the accreting millisecond X-ray pulsar MAXI J1957+032, covering two major outbursts in 2022 and 2025.
Li Zhaosheng, Kuiper Lucien, Pan Yuanyue, Xu Renxin, Ge Mingyu, Weng Shanshan, Peng Long, Yu Wenhui, Huang Yue, Zhang Liang, Song Liming, Molkov Sergey V., Lutovinov Alexander A., Zhang Shu, Zhang Shuang-Nan   +14 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Interaction between disk and extended corona in a general relativistic framework

Astronomy & Astrophysics
Context. The energy equilibrium between the corona and the underlying disk in a two-phase accretion flow sets a lower limit on the achievable photon index.
Datta Sudeb Ranjan, Bursa Michal, Dovciak Michal, Zhang Wenda   +3 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Polarization properties of thermal accretion disk emission

Astronomy & Astrophysics
The X-ray polarimetric observing window reopening is shedding new light on our current understanding of compact accreting sources. This is particularly true for stellar-mass black hole sources observed in the thermally dominated state, for which the ...
Marra L., Podgorný J., Taverna R., Matt G., Bianchi S., Dovčiak M., Goosmann R.   +6 more
doaj   +1 more source

Luminous Hot Accretion Disks [PDF]

Monthly Notices of the Royal Astronomical Society, 2001
We find a new two-temperature hot branch of equilibrium solutions for stationary accretion disks around black holes. In units of Eddington accretion rate defined as $10L_{\rm Edd}/c^2$, the accretion rates to which these solutions correspond are within the range $\dot{m}_1 \la \dot{m} \la 1$, here $\dot{m}_1$ is the critical rate of advecti$.
openaire   +3 more sources

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

The relationship between the emission line, continuum luminosity, and Baldwin effect in blazars

Astronomy & Astrophysics
Aims. This study investigates the relationship between the Mg II λ2798 Å emission line and the 3000 Å continuum luminosity, as well as the Baldwin effect, in a sample of 40’,685 radio-quiet (RQ) quasars and 441 flat spectrum radio quasars (FSRQs ...
Patiño-Álvarez Víctor M., Guerrero-González Jonhatan U., Chavushyan Vahram, Monjardin-Ward Douglas E., Arshakian Tigran G., Cruz-González Irene   +5 more
doaj   +1 more source