Results 211 to 220 of about 1,814 (268)

Stem Cell Differentiation Disperses Transcriptional Clusters via a Conserved Surface‐Condensate Trajectory

Advanced Science, EarlyView.
Stem cell differentiation follows a conserved surface condensate trajectory: H3K27ac super enhancers nucleate large RNA polymerase II clusters that grow and unfold before transcriptional activity disperses them. This work reveals how biophysical forces at enhancer surfaces dynamically build and dismantle stem cell transcription hubs, reshaping cell ...
Tim Klingberg, Irina Wachter, Agnieszka Pancholi, Matthias Akyel, Yomna Gohar, Priya Kumar, Ana Miguel Fernandes, Yuzhi Bao, Alica Schmidt‐Heydt, Marcel Piepers, Alicia Günthel, Marcel Sobucki, Elisa Kämmer, Süheyla Eroğlu‐Kayıkçı, Stephan Allgeier, Sylvia Erhardt, Vasily Zaburdaev, Carmelo Ferrai, Lennart Hilbert   +18 more
wiley   +1 more source

Entropy and Stability: Reduced Hamiltonian Formalism of Non-Barotropic Flows and Instability Constraints. [PDF]

Entropy (Basel)
Yahalom A.
europepmc   +1 more source

Dynamically Modified Flexible Zn Powder Anodes with Stable Performance at High Rate and High Zn Utilization

Advanced Science, EarlyView.
A dynamically shape‐variant liquid metal‐based network is integrated into Zn powder electrode, where intrinsic fluidity and structural adaptability of the liquid metal‐based network enable effective mitigation of dendritic growth, alleviation of stress accumulation, and prevention of Zn loss during Zn plating‐stripping processes.
Yuxuan Wang, Chenhao Li, Wenbo Zhao, Yong Gao, Yiwei Liu, Yuhao Li, Yu Zhang, Yuhan Yao, Abdelnaby M. Elshahawy, Cao Guan   +9 more
wiley   +1 more source

Radiative plasma simulations of black hole accretion flow coronae in the hard and soft states. [PDF]

Nat Commun
Nättilä J.
europepmc   +1 more source

Cholesterol‐Mediated Metabolic‐mechanotransductive Crosstalk Orchestrates Castration Resistance in Prostate Cancer

Advanced Science, EarlyView.
Full androgen deprivation (FAD) induces paracrine cholesterol in prostate cancer that drives the polarization of cancer‐associated fibroblasts (CAFs) and subsequent elevated matrix stiffness. Matrix stiffness in turn potentiates tumor cell survival under FAD pressure via dual mechanotransductive activation of the IRE1α‐XBP1s stress‐response axis ...
Shaojie Liu, Chao Xu, Jun Jiang, Limin He, Yike Zhou, Zhengxuan Li, Yu Li, Keying Zhang, Fa Yang, Tong Lu, Hongtao Song, Hai Zhu, Zhihao Hu, Xiaolong Zhao, Kai Gan, Hongji Li, Bo Yang, Rui Zhang, Weihong Wen, Donghui Han, Weijun Qin   +20 more
wiley   +1 more source

Coupling laboratory FTIR data with PROCODA kinetic modeling for the radiolysis of frozen formic acid using swift ions. [PDF]

RSC Adv
Moraes L, Fargnoli CM, Pilling S.
europepmc   +1 more source

Microblasting Wound Dressings Mechanically Disrupt Polymicrobial Biofilms to Enhance Healing in Treatment‐Resistant Wounds

Advanced Science, EarlyView.
Treatment‐resistant wounds caused by polymicrobial biofilms are refractory to conventional therapies due to the dense extracellular matrices. We developed μBLAST, a microblasting wound dressing that combines MnO2‐doped biosilica and a H2O2‐releasing mesh to generate localized oxygen microbubbles that mechanically disrupt biofilms.
Yujin Ahn, Joo Hun Lee, Christian Hurd, Jiye Lee, Junggeon Park, Adam A. Markowicz, Zheyuan Zhang, Joanne Hwang, Guillermo L. Monroy, Simon A. Rogers, Woonggyu Jung, Stephen A. Boppart, Hyunjoon Kong   +12 more
wiley   +1 more source

Quasi-periodic X-ray eruptions years after a nearby tidal disruption event. [PDF]

Nature
Nicholl M, Pasham DR, Mummery A, Guolo M, Gendreau K, Dewangan GC, Ferrara EC, Remillard R, Bonnerot C, Chakraborty J, Hajela A, Dhillon VS, Gillan AF, Greenwood J, Huber ME, Janiuk A, Salvesen G, van Velzen S, Aamer A, Alexander KD, Angus CR, Arzoumanian Z, Auchettl K, Berger E, de Boer T, Cendes Y, Chambers KC, Chen TW, Chornock R, Fulton MD, Gao H, Gillanders JH, Gomez S, Gompertz BP, Fabian AC, Herman J, Ingram A, Kara E, Laskar T, Lawrence A, Lin CC, Lowe TB, Magnier EA, Margutti R, McGee SL, Minguez P, Moore T, Nathan E, Oates SR, Patra KC, Ramsden P, Ravi V, Ridley EJ, Sheng X, Smartt SJ, Smith KW, Srivastav S, Stein R, Stevance HF, Turner SGD, Wainscoat RJ, Weston J, Wevers T, Young DR.   +63 more
europepmc   +1 more source

A Brain‐Penetrant Nanobody Reveals GSK3β‐Driven Proline‐Directed Phosphorylation as a Master Regulator of Ischemic Neurodegeneration

Advanced Science, EarlyView.
A brain‐targeted nanoparticle enables delivery of a therapeutic nanobody (Nb.29E9) that inhibits pathogenic GSK3β signaling. This intervention restores AMPK/mTORC1/TGFβ homeostasis, attenuates neuroinflammation and oxidative stress, and promotes long‐term functional recovery after ischemic stroke.
Lan Li, Muyang Li, Lei Sun, Ying Yang, Yuanshun Wu, Ziyi Yin, Anni Wang, Peiyang Zhou, Shaoxiang Luo, Jian Chen, Jun Qin, Zhibing Ai, Zilong Yuan, Zhiqiang Dong, Min Zhang   +14 more
wiley   +1 more source

An Abrupt Change in the Disk Fraction of Free-Floating Planets at the Deuterium-Burning Ignition Limit

Rodrigues T, Bouy H, Raymond S, Martín E, Bertin E, Romero JO, Barrado D, Huélamo N, Tamura M, Roig NM, Galli P, Cuillandre J.   +11 more
europepmc   +1 more source